Systemic cytokines and chemokines on admission of children hospitalized with community-acquired pneumonia

dc.creatorVasconcellos, Ângela Gomes de
dc.creatorClarêncio, Jorge
dc.creatorAndrade, Daniela Rodrigues
dc.creatorCardoso, Maria Regina Alves
dc.creatorBarral, Aldina Maria Prado
dc.creatorCarvalho, Cristiana Maria Costa Nascimento
dc.date2018-04-09T19:00:17Z
dc.date2018-04-09T19:00:17Z
dc.date2017
dc.date.accessioned2023-09-26T23:08:08Z
dc.date.available2023-09-26T23:08:08Z
dc.identifierVASCONCELLOS, A. G. et al. Systemic cytokines and chemokines on admission of children hospitalized with community-acquired pneumonia. Cytokine, 2017.
dc.identifier1043-4666
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25695
dc.identifier10.1016/j.cyto.2017.11.005
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8887232
dc.descriptionBahia State Agency for Research Funding (FAPESB) (grant no. PNX 0019/2009).
dc.descriptionCommunity-acquired pneumonia (CAP) is the main cause of death in children under-5 years worldwide and Streptococcus pneumoniae is the most common bacterial agent. However, it is difficult to identify pneumococcal infection among children with CAP. We aimed to assess association between any cytokine/chemokine and pneumococcal infection in childhood CAP. Furthermore, we evaluated the diagnostic value of cytokine/chemokine for pneumococcal infection. This prospective study was conducted at an Emergency Room, in Salvador, Brazil. Children <5-years-old hospitalized with CAP in a 21-month period were evaluated. On admission, clinical and radiological data were collected along with biological samples to investigate 20 etiological agents and determine serum cytokines (interleukin (IL)-8, IL-6, IL-10, IL-1β, IL-12, TNF-α, IL-2, IL-4, IL-5, γ-interferon), and chemokines (CCL2, CCL5, CXCL9, CXCL10) concentration. From 166 patients with etiology detected, pneumococcal infection was detected in 38 (22.9%) cases among which the median IL-6(pg/ml) was 31.2 (IQR: 12.4-54.1). The other 128 cases had other causative agents detected (Haemophilus influenzae, Moraxella catarrhalis, atypical bacteria and viruses) with the median IL-6 concentration being 9.0 (IQR: 4.1-22.0; p < 0.001). The area under the ROC curve for IL-6 to predict pneumococcal CAP was 0.74 (95%CI: 0.65-0.83; p < 0.001). By multivariate analysis, with pneumococcal CAP as dependent variable, IL-6 was an independent predictor for pneumococcal infection (OR = 5.56; 95%CI: 2.42-12.75, cut-off point = 12.5 pg/ml; p = 0.0001). The negative predictive value of IL-6 under 12.5 pg/ml for pneumococcal infection was 90% (95%CI: 82-95%). Independently significant difference was not found for any other cytokines/chemokines. Serum IL-6 concentration on admission is independently associated with pneumococcal infection among children under-5 years hospitalized with CAP.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectInfecção respiratória aguda
dc.subjectCriança
dc.subjectInfecção do trato respiratório inferior
dc.subjectDoença pulmonar
dc.subjectInfecção pneumocócica
dc.subjectAcute respiratory infection
dc.subjectChild
dc.subjectLower respiratory tract infection
dc.subjectLung disease
dc.subjectPneumococcal infection
dc.titleSystemic cytokines and chemokines on admission of children hospitalized with community-acquired pneumonia
dc.typeArticle


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