Evaluation of gold nanorods toxicity on isolated mitochondria

dc.creatorNunes, Ábner M.
dc.creatorSilva, Kleyton R. M. da
dc.creatorCalado, Claudia M. S.
dc.creatorSaraiva, Karina L. A.
dc.creatorFigueiredo, Regina C. B. Q.
dc.creatorLeite, Ana Catarina R.
dc.creatorMeneghetti, Mario R.
dc.date2019-10-14T14:44:43Z
dc.date2019-10-14T14:44:43Z
dc.date2019
dc.date.accessioned2023-09-26T23:07:48Z
dc.date.available2023-09-26T23:07:48Z
dc.identifierNUNES, Ábner M. et al. Evaluation of gold nanorods toxicity on isolated mitochondria. Toxicology, v. 413, p. 24-32, 2019.
dc.identifier0300-483X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/36414
dc.identifier10.1016/j.tox.2018.12.002
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8887179
dc.descriptionGold nanorods (AuNRs) have been studied extensively in biomedicine due to their biocompatibility and their unique properties. Some studies reported that AuNRs selectively accumulate on cancer cell mitochondria causing its death. However, the immediate effects of this accumulation needed further investigations. In this context, we evaluated the effect of AuNRs on the mitochondrial integrity of isolated rat liver mitochondria. We verified that AuNRs decreased the mitochondrial respiratory ratio by decreasing the phosphorylation and maximal states. Additionally, AuNRs caused a decrease in the production of mitochondrial ROS and a delay in mitochondrial swelling. Moreover, even with cyclosporine A treatment, AuNRs disrupted the mitochondrial potential. With the highest concentration of AuNRs studied, disorganized mitochondrial crests and intermembrane separation were observed in TEM images. These results indicate that AuNRs can interact with mitochondria, disrupting the electron transport chain. This study provides new evidence of the immediate effects of AuNRs on mitochondrial bioenergetics.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.rightsrestricted access
dc.subjectBioenergetics
dc.subjectGold
dc.subjectMitochondria
dc.subjectNanorods
dc.subjectAnimais
dc.subjectRelação Dose-Resposta a Droga
dc.subjectOuro / metabolismo
dc.subjectOuro / toxicidade
dc.subjectMasculino
dc.subjectMitocôndrias Hepáticas / efeitos dos fármacos
dc.subjectMitocôndrias Hepáticas / metabolismo
dc.subjectMitocôndrias Hepáticas / patologia
dc.subjectNanotubos / toxicidade
dc.subjectConsumo de Oxigênio / efeitos dos fármacos
dc.subjectConsumo de Oxigênio / fisiologia
dc.subjectRatos
dc.subjectRatos Wistar
dc.titleEvaluation of gold nanorods toxicity on isolated mitochondria
dc.typeArticle


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