Epidermal growth factor receptors, testosterone levels and parotid gland changes in rats infected with Trypanosoma cruzi

dc.creatorAguirre, Kezia L. H.
dc.creatorAlves, José B
dc.creatorSilva, Gerluza Aparecida Borges
dc.creatorCardoso, Jarbas E
dc.creatorMurta, Silvane Maria Fonseca
dc.creatorFerreira, Anderson J
dc.date2023-05-26T18:33:23Z
dc.date2023-05-26T18:33:23Z
dc.date2009
dc.date.accessioned2023-09-26T23:07:40Z
dc.date.available2023-09-26T23:07:40Z
dc.identifierAGUIRRE, Kezia LH et al. Epidermal growth factor receptors, testosterone levels and parotid gland changes in rats infected with Trypanosoma cruzi. Mem. Inst. Oswaldo Cruz, v. 104, n. 5, p. 715-719, 2009. doi.org/10.1590/S0074-02762009000500009
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/58758
dc.identifierhttps://doi.org/10.1590/S0074-02762009000500009
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8887153
dc.descriptionIt has been demonstrated that parotid glands of rats infected with Trypanosoma cruzi present severe histological alterations; changes include reduction in density and volume of the acini and duct systems and an increase in connective tissue. We evaluated the association between morphological changes in parotid glands, circulating testosterone levels and epidermal growth factor receptor (EGF-R) expression in experimental Chagas disease in rats. Animals at 18 days of infection (acute phase) showed a significant decrease in body weight, serum testosterone levels and EGF-R expression in the parotid gland compared with a control group. Since decreases in body weight could lead to a reduction in circulating testosterone concentration, we believe that the reduction in EGF-R expression in parotid glands of infected rats is due to alterations in testosterone levels and atrophy of parotid glands is caused by changes in EGF-R expression. Additionally, at 50 days (chronic phase) of infection parotid glands showed a normal histological aspect likely due to the normalization of the body weight. These findings suggest that the testosterone-EGF-R axis is involved in the histological changes
dc.formatapplication/pdf
dc.languageeng
dc.publisherMinistério da Saúde
dc.rightsopen access
dc.subjectparotid glands
dc.subjecthistological alterations
dc.subjectChagas disease
dc.subjecttestosterone
dc.subjectEGF-receptor
dc.titleEpidermal growth factor receptors, testosterone levels and parotid gland changes in rats infected with Trypanosoma cruzi
dc.typeArticle


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