Natural killer T cells are required for the development of a superantigen-driven T helper type 2 immune response in mice

dc.creatorNomizo, Auro
dc.creatorPostol, Edilberto
dc.creatorAlencar, Raquel de
dc.creatorCardillo, Fabíola
dc.creatorMengele Junior, José Orivaldo
dc.date2017-07-05T13:34:08Z
dc.date2017-07-05T13:34:08Z
dc.date2005
dc.date.accessioned2023-09-26T23:07:13Z
dc.date.available2023-09-26T23:07:13Z
dc.identifierNOMIZO, A. et al. Natural killer T cells are required for the development of a superantigen-driven T helper type 2 immune response in mice. Immunology, v. 116, p. 233–244, 2005.
dc.identifier0019-2805
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/19721
dc.identifier10.1111/j.1365-2567.2005.02215.x
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8887065
dc.descriptionCardillo, Fabíola; Mengel, José “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
dc.descriptionCNPq and FAPESP (proc. 95/09379-2 and 97/6225-0) and by fellowships from CNPq (J.M.), FAPESP (F.C., R.A. and E.P.) and CAPES (A.N., E.P. and R.A.).
dc.descriptionWe show, here, that one single injection or weekly injections of staphylococcal enterotoxin B (SEB), starting in 1-day-old newborn mice, induced a powerful immune response with a T helper type 2 (Th2) pattern, as judged by the isotype and cytokine profile, with the production of large amounts of SEB-specific immunoglobulin G1 (IgG1), detectable levels of SEB-specific IgE and increased production of interleukin-4 by spleen cells. These protocols also induced an increase in the levels of total IgE in the serum. Memory of SEB was transferred to secondary recipients by using total spleen cells from primed animals. The secondary humoral response in transferred mice was diminished if spleen cells from SEB-treated mice were previously depleted of CD3+ or Vbeta8+ T cells or NK1.1+ cells. In vivo depletion of NK1.1+ cells in adult mice resulted in a marked reduction in the SEB-specific antibody response in both the primary and secondary immune responses. Additionally, purified NK1.1+ T cells were able to perform SEB-specific helper B-cell actions in vitro and in vivo. These results suggest that NK1.1+ T cells are required for the full development of humoral immunological memory, whilst making neonatal tolerance to SEB unachievable.
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsopen access
dc.subjectImunoglobulina G
dc.subjectCélulas T assassinas naturais
dc.subjectEnterotoxina B estafilocócica
dc.subjectSuperantígenos
dc.subjectTolerância
dc.subjectimmunoglobulin G
dc.subjectNatural killer T cells
dc.subjectStaphylococcal enterotoxin B
dc.subjectSuperantigens
dc.subjectTolerance
dc.titleNatural killer T cells are required for the development of a superantigen-driven T helper type 2 immune response in mice
dc.typeArticle


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