RNA interference-mediated knockdown of CD49e (α5 integrin chain) in human thymic epithelial cells modulates the expression of multiple genes and decreases thymocyte adhesion

dc.creatorLacerda, Leandra Linhares
dc.creatorAlves, Marcelo Ribeiro
dc.creatorNogueira, Ana Cristina Martins de Almeida
dc.creatorCruz, Daniella Arêas Mendes da
dc.creatorMagalhães, Danielle Aparecida
dc.creatorDardenne, Mireille
dc.creatorPassos, Geraldo Aleixo
dc.creatorSavino, Wilson
dc.date2018-04-12T15:28:34Z
dc.date2018-04-12T15:28:34Z
dc.date2010
dc.date.accessioned2023-09-26T23:06:28Z
dc.date.available2023-09-26T23:06:28Z
dc.identifierLACERDA, Leandra Linhares et al. RNA interference-mediated knockdown of CD49e (a5 integrin chain) in human thymic epithelial cells modulates the expression of multiple genes and decreases thymocyte adhesion. BMC Genomics, v.1, Suppl. 5, p. :S2, 13 p, 2010.
dc.identifier1471-2164
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/25815
dc.identifier10.1186/1471-2164-11-S5-S2
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8886923
dc.descriptionFrom 5th International Conference of the Brazilian Association for Bioinformatics and Computational Biology (X-meeting 2009) Angra Dos Reis, RJ, Brazil. 18-22 October 2009
dc.descriptionThe thymus is a central lymphoid organ, in which bone marrow-derived T cell precursors undergo a complex process of maturation. Developing thymocytes interact with thymic microenvironment in a defined spatial order. A component of thymic microenvironment, the thymic epithelial cells, is crucial for the maturation of T-lymphocytes through cell-cell contact, cell matrix interactions and secretory of cytokines/chemokines. There is evidence that extracellular matrix molecules play a fundamental role in guiding differentiating thymocytes in both cortical and medullary regions of the thymic lobules. The interaction between the integrin α5β1 (CD49e/CD29; VLA-5) and fibronectin is relevant for thymocyte adhesion and migration within the thymic tissue. Our previous results have shown that adhesion of thymocytes to cultured TEC line is enhanced in the presence of fibronectin, and can be blocked with anti-VLA-5 antibody.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBioMed Central
dc.rightsopen access
dc.subjectRegulação gênica
dc.subjectadesão de células heterocelulares
dc.subjectTimócitos
dc.subjectmicroambiente tímico
dc.subjectcélulas T intratímicas
dc.subjectgene regulation
dc.subjectheterocellular cell adhesion
dc.subjectgene regulation
dc.subjectthymocytes
dc.subjectthymic microenvironment
dc.subjectcd49E
dc.titleRNA interference-mediated knockdown of CD49e (α5 integrin chain) in human thymic epithelial cells modulates the expression of multiple genes and decreases thymocyte adhesion
dc.typeArticle


Este ítem pertenece a la siguiente institución