Evaluation of memory immune response to mycobacterium extract among household contact of tuberculosis cases

dc.creatorCavalcanti, Y. V. N.
dc.creatorPereira, V. R. A.
dc.creatorReis, L. C.
dc.creatorRamos, A. L. G.
dc.creatorLuna, C. F.
dc.creatorNascimento, E. J. M.
dc.creatorLucena-Silva, N.
dc.date2018-08-08T11:47:45Z
dc.date2018-08-08T11:47:45Z
dc.date2009
dc.date.accessioned2023-09-26T23:05:59Z
dc.date.available2023-09-26T23:05:59Z
dc.identifierCAVALCANTI, Y. V. N. et al. Evaluation of Memory Immune Response to Mycobacterium Extract among Household Contact of Tuberculosis Cases. Journal of Clinical Laboratory Analysis, v. 23, n. 1, p. 57–62, 2009.
dc.identifier1098-2825
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/27995
dc.identifier10.1002/jcla.20290
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8886830
dc.descriptionThe human immune response to tuberculosis (TB) is especially mediated by T CD4(+)lymphocytes. However, more studies are needed in order to understand the exact role of each cytokine in the mechanisms for cures. In this article, our aim was to analyze the production of TNF-alpha, IL-10, and IFN-gamma in peripheral blood mononuclear cells (PBMCs) among the household contacts of common primary TB cases, with or without histories of active TB infection, who were negative to parasitological and HIV tests. In order to characterize the cytokine production, PBMCs from these groups were stimulated with whole-protein extract of M. tuberculosis (WPE) antigen (rAgTb) for 24 and 48 hr. The culture supernatants were collected and IFN-gamma, TNF-alpha, and IL-10 were assayed using capture ELISA. There were no statistical differences between primary TB cases and their household contacts with or without previous histories of lung TB. Our results suggest that T memory cells, T regulatory cells, and the Th1/Th2 dichotomy may be responsible for the results described in this article. Further studies are currently underway.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.rightsrestricted access
dc.subjecttuberculose
dc.subjectcontato domiciliar
dc.subjectcitocina
dc.subjecttuberculosis
dc.subjecthousehold contact
dc.subjectcytokine
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectEnvelhecido
dc.subjectIdoso, 80 anos ou mais
dc.subjectAntígenos Bacterianos / imunologia
dc.subjectBrasil
dc.subjectEstudos de caso-controle
dc.subjectCélulas Cultivadas / imunologia
dc.subjectCitocinas / análise
dc.subjectCitocinas / imunologia
dc.subjectExposição Ambiental
dc.subjectFêmea
dc.subjectHumanos
dc.subjectMemória Imunológica / imunologia
dc.subjectInterferon-gama / análise
dc.subjectInterferona-gama / imunologia
dc.subjectInterleucina-10 / análise
dc.subjectInterleucina-10 / imunologia
dc.subjectLeucócitos Mononucleares / imunologia
dc.subjectMasculino
dc.subjectMeia idade
dc.subjectMycobacterium tuberculosis / imunologia
dc.subjectEstatísticas não paramétricas
dc.subjectTeste de tuberculina
dc.subjectTuberculose / imunologia
dc.subjectTuberculose / microbiologia
dc.subjectFator de Necrose Tumoral alfa / de análise
dc.subjectFator de Necrose Tumoral alfa / imunologia
dc.titleEvaluation of memory immune response to mycobacterium extract among household contact of tuberculosis cases
dc.typeArticle


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