Efficient in vitro expansion of JC virus-specific CD8+ T-cell responses by JCV peptide-stimulated dendritic cells from patients with progressive multifocal leukoencephalopathy

dc.creatorMarzocchetti, Angela
dc.creatorLima, Marco
dc.creatorTompkins, Troy
dc.creatorKavanagh, Daniel.G
dc.creatorGandhi, Rajesh T.
dc.creatorO'Neill, David W.
dc.creatorBhardwaj, Nina
dc.creatorKoralnik, Igor J.
dc.date2019-12-23T13:30:13Z
dc.date2019-12-23T13:30:13Z
dc.date2009
dc.date.accessioned2023-09-26T23:05:46Z
dc.date.available2023-09-26T23:05:46Z
dc.identifierMARZOCCHETTI, Angela et al. Efficient in vitro expansion of JC virus-specific CD8+ T-cell responses by JCV peptide-stimulated dendritic cells from patients with progressive multifocal leukoencephalopathy. Virology, v. 383, n. 2, p. 173-177, Jan. 2009.
dc.identifier0042-6822
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/38791
dc.identifier10.1016/j.virol.2008.10.046
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8886786
dc.descriptionProgressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the brain caused by JC virus (JCV) for which there is no cure. PML patients who have JCV-specific CD8+ cytotoxic T lymphocytes (CTL) in their blood have a better clinical outcome. We compared JCV-specific CTL responses in vitro elicited either by JCV peptide-loaded dendritic cells (DC) or by direct peptide stimulation of lymphocytes from 20 HLA A*0201+ healthy controls, HIV+ and PML patients. JCV peptide-loaded DC elicited a stronger CTL expansion in 13/15 responders. DC can induce potent JCV-specific CTL response in vitro, and may constitute a promising approach for PML immunotherapy.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectJC virus
dc.subjectProgressive multifocal leukoencephalopathy
dc.subjectDendritic cells
dc.titleEfficient in vitro expansion of JC virus-specific CD8+ T-cell responses by JCV peptide-stimulated dendritic cells from patients with progressive multifocal leukoencephalopathy
dc.typeArticle


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