Poisoning of mice by Baccharis coridifolia: An experimental model

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorVaraschin, Mary Suzan
dc.creatorAlessi, Antonio Carlos
dc.date2014-05-27T11:20:37Z
dc.date2016-10-25T18:18:26Z
dc.date2014-05-27T11:20:37Z
dc.date2016-10-25T18:18:26Z
dc.date2003-02-01
dc.date.accessioned2017-04-06T01:05:00Z
dc.date.available2017-04-06T01:05:00Z
dc.identifierVeterinary and Human Toxicology, v. 45, n. 1, p. 42-44, 2003.
dc.identifier0145-6296
dc.identifierhttp://hdl.handle.net/11449/67197
dc.identifierhttp://acervodigital.unesp.br/handle/11449/67197
dc.identifierWOS:000180615700016
dc.identifier2-s2.0-0037307552
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/12583700
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/888677
dc.descriptionThe poisonous plant Baccharis coridifotia causes necrosis in lymphoid tissues and the gastrointestinal tract of cattle, horses, sheep and rabbits. An experimental poisoning of mice was undertaken to establish an experimental model in a laboratory animal specie. A single 5 to 8-g/kg dose of a suspension of the plant was administered by gavage to II mice. To 3 other control mice, the same volume of water was administered. Plant-dosed mice manifested clinical effects after 12 h: tachipnea, trembles, dehydration and prostration. Most of the dosed mice died 14 to 33 h after plant administration-3 survived for 12 d. Six mice had remarkable necrosis of the germinative center of secondary follicles in lymph nodes and spleen; 3 mice had necrosis of lymphoid tissues in intestine and thymus. Mice reproduce most of the lesions observed in naturally poisoned cattle and the use of this specie as an experimental model is valid.
dc.languageeng
dc.relationVeterinary and Human Toxicology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectBaccharis cordifolia
dc.subjectcattle
dc.subjectcontrolled study
dc.subjectdehydration
dc.subjectfemale
dc.subjectgastrointestinal tract
dc.subjecthorse
dc.subjectlymphoid tissue
dc.subjectmale
dc.subjectmouse
dc.subjectnonhuman
dc.subjectplant
dc.subjectplant intoxication
dc.subjectrabbit
dc.subjectsheep
dc.subjecttachypnea
dc.subjecttissue necrosis
dc.subjectAdministration, Oral
dc.subjectAnimals
dc.subjectBaccharis
dc.subjectDisease Models, Animal
dc.subjectDose-Response Relationship, Drug
dc.subjectFemale
dc.subjectLiver
dc.subjectLymph Nodes
dc.subjectMale
dc.subjectMice
dc.subjectPlant Poisoning
dc.subjectPlants, Toxic
dc.subjectPoisoning
dc.subjectSpleen
dc.subjectAnimalia
dc.subjectBos taurus
dc.subjectEquidae
dc.subjectEquus caballus
dc.subjectOryctolagus cuniculus
dc.subjectOvis aries
dc.titlePoisoning of mice by Baccharis coridifolia: An experimental model
dc.typeOtro


Este ítem pertenece a la siguiente institución