Stage specific gene expression precedes morphological changes during Trypanosoma cruzi metacyclogenesis

dc.creatorContreras, Victor T.
dc.creatorMorel, Carlos Medicis
dc.creatorGoldenberg, Samuel
dc.date2016-06-28T16:12:03Z
dc.date2016-07-07T12:16:34Z
dc.date2016-06-28T16:12:03Z
dc.date2016-07-07T12:16:34Z
dc.date1985
dc.date.accessioned2023-09-26T23:05:35Z
dc.date.available2023-09-26T23:05:35Z
dc.identifierCONTRERAS, Victor T.; MOREL, Carlos M.; GOLDENBERG, Samuel. Stage specific gene expression precedes morphological changes during Trypanosoma cruzi metacyclogenesis. Molecular and Biochemical Parasitology, v.14, p.83-96, 1985.
dc.identifier1872-9428
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/14684
dc.identifier0166-6851
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8886750
dc.descriptionThe transformation of epimastigotes to metacyclic trypomastigotes of the Trypanosoma cruzi clone Dm 28c has been studied in an in vitro system consisting of artificial triatomine urine supplemented with new born calf serum. The comparison of morphological data with gene expression products, as judged by the proteins synthesized during differentiation, has shown that stage specific gene activation precedes by far the morphological changes of differentiating cells. Immunoprecipitation of differentiating cell antigens with a trypomastigote stage specific antiserum has shown that although the morphological differentiation process takes six days to be completed, epimastigotes start to express the M 86 000 and the 78 000 trypomastigote antigens within the first 12 h of induction.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectChagas' disease
dc.subjectTrypanosoma cruzi cloned strain
dc.subjectGene expression
dc.subjectCell differentiation
dc.subjectDiferenciação Celular
dc.subjectDoença de Chagas
dc.subjectTrypanosoma cruzi
dc.subjectExpressão Gênica
dc.titleStage specific gene expression precedes morphological changes during Trypanosoma cruzi metacyclogenesis
dc.typeArticle


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