Interleukin-2 production during murine infection by Leishmania mexicana amazonensis.

dc.creatorBarral Netto, Manoel
dc.creatorRoters, Silene B.
dc.creatorBarral, Aldina Maria Prado
dc.date2014-03-28T13:20:17Z
dc.date2014-03-28T13:20:17Z
dc.date1986
dc.date.accessioned2023-09-26T23:05:25Z
dc.date.available2023-09-26T23:05:25Z
dc.identifierBARRAL-NETTO, M.; ROTERS, S. B.; BARRAL, A. Interleukin-2 production during murine infection by Leishmania mexicana amazonensis. Memórias do Instituto Oswaldo Cruz, v. 81, n. 1, p. 43-47, 1986.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7466
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8886718
dc.descriptionHighly susceptible BALB/c mice, resistant C57B1/6 and their F1 progeny (BDF1) were infected subcutaneously in the foot pad with Leishmania mexicana amazonensis. At various times after infection, spleen or draining popliteal lymph node cells were assayed for their capacity to generate Interleukin-2 (I1-2) by Concanavalin A (ConA) stimulation. In both BALB/c and C57B1/6 strains there was a transient increase in their capacity to produce I1-2, from the 3rd to the 10th week post-infection. Return to pre-infection levels occurred between 13th to 16th week post-infection in all three strains. BALB/c mice always produced higher titers of I1-2 than C57B1/6, but such differences were statistically significant only at 3 and 10 weeks post-infection. BDF1 mice had titers similar to those observed in BALB/c mice. I1-2 production by ConA-stimulated lymph node cells was lower as compared to the spleen, but with a similar pattern among the three mice strains. Our data show that susceptibility to infection by L. mexicana amazonensis is not associated with deficient ConA-stimulated I1-2 production.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFiocruz
dc.rightsopen access
dc.subjectCutaneous leishmaniasis
dc.subjectInterleukin-2
dc.subjectLeishmania (immunology)
dc.subjectMurine leishmaniasis
dc.subjectLymphokines
dc.subjectConcanavalina A/farmacologia
dc.subjectInterleucina-2/biossíntese
dc.subjectLeishmaniose/imunologia
dc.subjectBaço/imunologia
dc.subjectAnimais
dc.subjectLeishmania mexicana/imunologia
dc.subjectCamundongos
dc.subjectCamundongos Endogâmicos BALB C
dc.subjectCamundongos Endogâmicos C57BL
dc.titleInterleukin-2 production during murine infection by Leishmania mexicana amazonensis.
dc.typeArticle


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