Long non-coding RNAs are differentially expressed after different exercise training programs

dc.creatorBonilauri, Bernardo
dc.creatorDallagiovanna, Bruno
dc.date2020-11-19T18:48:53Z
dc.date2020-11-19T18:48:53Z
dc.date2020
dc.date.accessioned2023-09-26T23:05:11Z
dc.date.available2023-09-26T23:05:11Z
dc.identifierBONILAURI, Bernardo; DALLAGIOVANNA, Bruno. Long non-coding RNAs are differentially expressed after different exercise training programs. Front. Physiol. V.11, n. 567614, p. 1-10, 2020.
dc.identifier1664-042X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/44549
dc.identifier10.3389/fphys.2020.567614
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8886670
dc.descriptionMolecular regulation related to the health benefits of different exercise modes remains unclear. Long non-coding RNAs (lncRNAs) have emerged as an RNA class with regulatory functions in health and diseases. Here, we analyzed the expression. of lncRNAs after different exercise training programs and their possible modes of action related to physical exercise adaptations. As methods: Public high-throughput RNA-seq data (skeletal muscle biopsies) were downloaded, and bioinformatics analysis was performed. We primarily analyzed data reports of 12 weeks of resistance training (RT), high-intensity interval training (HIIT), and combined (CT) exercise training. In addition, we analyzed data from 8 weeks of endurance training (ET). Differential expression analysis of lncRNAs was performed, and an adjusted P-value < 0.1 and log2 (fold change) ≥0.5 or ≤−0.5 were set as the cutoff values to identify differentially expressed lncRNAs (DELs). In the results: We identified 204 DELs after 12 weeks of HIIT, 43 DELs after RT, and 15 DELs after CT. Moreover, 52 lncRNAs were differentially expressed after 8 weeks of ET. The lncRNA expression pattern after physical exercise was very specific, with distinct expression profiles for the different training programs, where few lncRNAs were common among the exercise types. LncRNAs may regulate molecular responses to exercise, such as collagen fibril organization, extracellular matrix organization, myoblast and plasma membrane fusion, skeletal muscle contraction, synaptic transmission, PI3K and TORC regulation, autophagy, and angiogenesis. Conclusion: For the first time, we show that lncRNAs are differentially expressed in skeletal muscle after different physical exercise programs, and these lncRNAs may act in various biological processes related to physical activity adaptations.
dc.formatapplication/pdf
dc.languagepor
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectRNA Longo não Codificante
dc.subjectlncRNAs
dc.subjectExercise
dc.subjectPhysical Conditioning, Human
dc.subjectMuscles
dc.subjectHIIT
dc.subjectHigh-Intensity Interval Training
dc.subjectARN Largo no Codificante
dc.subjectEjercicio Físico
dc.subjectAcondicionamiento Físico Humano
dc.subjectEntrenamiento de Intervalos de Alta Intensidad
dc.subjectARN long non codant
dc.subjectExercice physique
dc.subjectMise en condition physique de l'homme
dc.subjectEntrainement fractionné de haute intensité
dc.subjectRNA Longo não Codificante
dc.subjectExercício Físico
dc.subjectCondicionamento Físico Humano
dc.subjectRNA-Seq
dc.subjectMúsculos
dc.subjectTreinamento Intervalado de Alta Intensidade
dc.titleLong non-coding RNAs are differentially expressed after different exercise training programs
dc.typeArticle


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