Correlation of antifungal susceptibility and molecular type within the Cryptococcus neoformans/C. gattii species complex

dc.creatorTrilles, Luciana
dc.creatorMeyer, Wieland
dc.creatorWanke, Bodo
dc.creatorGuarro, Josep
dc.creatorLazéra, Marcia
dc.date2019-11-18T12:37:59Z
dc.date2019-11-18T12:37:59Z
dc.date2012
dc.date.accessioned2023-09-26T23:05:05Z
dc.date.available2023-09-26T23:05:05Z
dc.identifierTRILLES, Luciana et al. Correlation of antifungal susceptibility and molecular type within the Cryptococcus neoformans/C. gattii species complex. Medical Mycology, v. 50, p. 328-332, Apr. 2012.
dc.identifier1369-3786
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/37104
dc.identifier10.3109/13693786.2011.602126
dc.identifier1460-2709
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8886652
dc.descriptionMembers of the Cryptococcus neoformans/C. gattii species complex are grouped into eight molecular types, differing in their epidemiology, disease severity and geographic range. Recent in vitro antifungal susceptibility studies of isolates of the complex revealed contradictory results. The objective of the present study was to assess if this variation is random or correlates with different molecular types by testing the in vitro antifungal susceptibility of 18 C. neoformans (VNI), 11 C. gattii (VGI) and 38 C. gattii (VGII) strains from Brazil to eight antifungal drugs using the CLSI microdilution method. We herein report that the molecular type VGII is the least susceptible genotype, followed by VGI and VNI. This indicates a clear correlation between antifungal susceptibilities and genotypes of the causative cryptococcosis agents, emphasizing the importance of determining the molecular type as part of the clinical diagnostic process to enable an informed decision as to the most appropriate antifungal treatment.
dc.description2020-11-18
dc.formatapplication/pdf
dc.languageeng
dc.publisherOxford University Press
dc.rightsopen access
dc.subjectCryptococcus neoformans
dc.subjectCryptococcus gattii
dc.subjectMolecular types
dc.subjectAntifungal susceptibility
dc.titleCorrelation of antifungal susceptibility and molecular type within the Cryptococcus neoformans/C. gattii species complex
dc.typeArticle


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