"In vivo" kinetics of eosinophils and mast cells in experimental murine schistosomiasis.

dc.creatorLenzi, Henrique Leonel
dc.creatorSobral, A. C.
dc.creatorLenzi, Jane A.
dc.date2012-02-28T17:07:18Z
dc.date2012-02-28T17:07:18Z
dc.date1987
dc.date.accessioned2023-09-26T23:04:54Z
dc.date.available2023-09-26T23:04:54Z
dc.identifierLENZI, H. L. ; SOBRAL, A. C. L.; LENZI, J. A. In vivo kinetics of eosinophils and mast cells in experimental murine Schistosomiasis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v.82, supl.4, p. 67-76, 1987.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/3786
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8886614
dc.descriptionDuring the schistosomiasis infection there is a "dance of the cells", varying from site to site and related to the time of infection. 1--Eosinophil levels exhibit a bimodal pattern, with the first peak related to the egg deposition and maturation and increased Kupfferian hyperplasia; the second peak precedes the death of some adult worms; 2--The peritoneal eosinophilic levels are inversely proportional to the blood eosinophilic levels; 3--Eosinopoiesis in the bone marrow begins at day 40, reaching the highest levels at day 50 and coincides with hepatic eosinophilic and neutrophilic metaplasia; 4--Peritoneal mast cell levels present a bimodal pattern similar to the blood eosinophils, and inverse to the peritoneal eosinophils. They also show a cyclic behaviour within the hepatic and intestinal granulomas. Integral analysis of the events related to the eosinophils in the blood, bone marrow, peritoneal cavity and hepatic and intestinal granulomas allows the detection of two important eosinophilic phases: the first is due to mobilization and redistribution of the marginal pool and the second originates from eosinophilic production in the bone marrow and liver. The productive phase is characterized by an increase in the number of eosinophils and monocyte/macrophages, and a decrease in neutrophils and stabilization of megakariocytes and erithroid lineages.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.rightsopen access
dc.subjectAnimals
dc.subjectEosinophils, pathology
dc.subjectSchistosomiasis mansoni, pathology
dc.subjectGranuloma, pathology
dc.subjectCell division
dc.subjectAnimais
dc.subjectEosinófilos
dc.subjectSchistosomiasis mansoni
dc.subjectGranuloma
dc.subjectDivisão celular
dc.subjectPatologia
dc.title"In vivo" kinetics of eosinophils and mast cells in experimental murine schistosomiasis.
dc.typeArticle


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