Neuroendocrine alterations impair enamel mineralization, tooth eruption and saliva in rats.

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSassaki, Kikue Takebayashi
dc.creatorDelbem, Alberto Carlos Botazzo
dc.creatordos Santos, Otoniel Antonio
dc.creatorShimabucoro, Carlos Eduardo
dc.creatorNakamune, Ana Cláudia
dc.creatorBedran-de-Castro, João César
dc.creatorOliveira-Filho, Ricardo Martins
dc.date2014-05-27T11:20:36Z
dc.date2016-10-25T18:18:23Z
dc.date2014-05-27T11:20:36Z
dc.date2016-10-25T18:18:23Z
dc.date2003-01-01
dc.date.accessioned2017-04-06T01:04:46Z
dc.date.available2017-04-06T01:04:46Z
dc.identifierPesquisa odontologica brasileira = Brazilian oral research, v. 17, n. 1, p. 5-10, 2003.
dc.identifier1517-7491
dc.identifierhttp://hdl.handle.net/11449/67167
dc.identifierhttp://acervodigital.unesp.br/handle/11449/67167
dc.identifier10.1590/S1517-74912003000100002
dc.identifierS1517-74912003000100002
dc.identifier2-s2.0-0142058016.pdf
dc.identifier2-s2.0-0142058016
dc.identifier0000-0002-8159-4853
dc.identifierhttp://dx.doi.org/10.1590/S1517-74912003000100002
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/888651
dc.descriptionNeonatal administration of monosodium glutamate (MSG) in rats causes definite neuroendocrine disturbances which lead to alterations in many organ systems. The possibility that MSG could affect tooth and salivary gland physiology was examined in this paper. Male and female pups were injected subcutaneously with MSG (4 mg/g BW) once a day at the 2nd, 4th, 6th, 8th and 10th day after birth. Control animals were injected with saline, following the same schedule. Lower incisor eruption was determined between the 4th and the 10th postnatal days, and the eruption rate was measured between the 43rd and the 67th days of age. Pilocarpine-stimulated salivary flow was measured at 3 months of age; protein and amylase contents were thereby determined. The animals treated with MSG showed significant reductions in the salivary flow (males, -27%; females, -40%) and in the weight of submandibular glands (about -12%). Body weight reduction was only about 7% for males, and did not vary in females. Saliva of MSG-treated rats had increased concentrations of total proteins and amylase activity. The eruption of lower incisors occurred earlier in MSG-treated rats than in the control group, but on the other hand the eruption rate was significantly slowed down. The incisor microhardness was found to be lower than that of control rats. Our results show that neonatal MSG treatment causes well-defined oral disturbances in adulthood in rats, including salivary flow reduction, which coexisted with unaltered protein synthesis, and disturbances of dental mineralization and eruption. These data support the view that some MSG-sensitive hypothalamic nuclei have an important modulatory effect on the factors which determine caries susceptibility.
dc.languageeng
dc.relationPesquisa Odontológica Brasileira = Brazilian Oral Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectamylase
dc.subjectfood additive
dc.subjectglutamate sodium
dc.subjectanimal
dc.subjectbody weight
dc.subjectdrug effect
dc.subjectenamel
dc.subjectfemale
dc.subjectmale
dc.subjectmetabolism
dc.subjectneurosecretion
dc.subjectnewborn
dc.subjectrat
dc.subjectsaliva
dc.subjectsalivary gland
dc.subjectsalivation
dc.subjectsex difference
dc.subjecttooth eruption
dc.subjectWistar rat
dc.subjectAmylases
dc.subjectAnimals
dc.subjectAnimals, Newborn
dc.subjectBody Weight
dc.subjectDental Enamel
dc.subjectFemale
dc.subjectFood Additives
dc.subjectMale
dc.subjectNeurosecretory Systems
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSaliva
dc.subjectSalivary Glands
dc.subjectSalivation
dc.subjectSex Factors
dc.subjectSodium Glutamate
dc.subjectTooth Eruption
dc.titleNeuroendocrine alterations impair enamel mineralization, tooth eruption and saliva in rats.
dc.typeOtro


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