| dc.creator | Pontes, Gina | |
| dc.creator | Latorre-Estivalis, José Manuel | |
| dc.creator | Gutiérrez, María Laura | |
| dc.creator | Cano, Agustina | |
| dc.creator | Astrada, Martin Berón de | |
| dc.creator | Lorenzo, Marcelo Gustavo | |
| dc.creator | Barrozo, Romina B | |
| dc.date | 2023-01-25T19:33:08Z | |
| dc.date | 2023-01-25T19:33:08Z | |
| dc.date | 2022 | |
| dc.date.accessioned | 2023-09-26T23:04:17Z | |
| dc.date.available | 2023-09-26T23:04:17Z | |
| dc.identifier | PONTES, Gina et al. Molecular and functional basis of high-salt avoidance in a blood-sucking insect. iScience, v. 25, n. 7, 104502, 2022. doi: 10.1016/j.isci.2022.104502 | |
| dc.identifier | 2589-0042 | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/56623 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8886498 | |
| dc.description | Salts are essential nutrients required for many physiological processes, and accordingly, their composition and concentration are tightly regulated. Taste is the ultimate sensory modality involved in resource quality assessment, resulting in acceptance or rejection. Here we found that high salt concentrations elicit feeding avoidance in the blood-sucking bug Rhodnius prolixus and elucidate the molecular and neurophysiological mechanisms involved. We found that high-salt avoidance is mediated by a salt-sensitive antennal gustatory receptor neuron (GRN). Using RNAi, we demonstrate that this process requires two amiloride-sensitive pickpocket channels (PPKs; Rpro PPK014276 and Rpro PPK28) expressed within these cells. We found that antennal GRNs project to the insect primary olfactory center, the antennal lobes, revealing these centers as potential sites for the integration of taste and olfactory host-derived cues. Moreover, the identification of the gustatory basis of high-salt detection in a hematophagous insect suggests novel targets for the prevention of biting and feeding. | |
| dc.description | 2025-12-31 | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Cell Press | |
| dc.rights | restricted access | |
| dc.subject | Biological sciences | |
| dc.subject | Neuroscience | |
| dc.subject | Sensory neuroscience | |
| dc.title | Molecular and functional basis of high-salt avoidance in a blood-sucking insect | |
| dc.type | Article | |
