Brasil | Article

Pivotal role for TGF-beta in infectious heart disease: The case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy

dc.creatorAraujo-Jorge, Tania C.
dc.creatorWaghabi, Mariana C.
dc.creatorSoeiro, Maria de Nazaré C.
dc.creatorKeramidas, Michelle
dc.creatorBailly, Sabine
dc.creatorFeige, Jean-Jacques
dc.date2019-04-02T16:58:21Z
dc.date2019-04-02T16:58:21Z
dc.date2008
dc.date.accessioned2023-09-26T23:03:41Z
dc.date.available2023-09-26T23:03:41Z
dc.identifierARAUJO-JORGE, Tania C. et al. Pivotal role for TGF-b in infectious heart disease: The case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy. Cytokine & Growth Factor Reviews, v. 19, p. 405-413, Oct. 2008.
dc.identifier1359-6101
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/32333
dc.identifier10.1016/j.cytogfr.2008.08.002
dc.identifier1879-0305
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8886391
dc.descriptionThis paper summarizes recent data from the literature suggesting that transforming growth factor-beta (TGF-beta) participates at least in four different processes influencing development of myocardiopathy in Chagas disease, a major parasitic illness caused by Trypanosoma cruzi infection: (a) invasion of cardiac fibroblasts and myocytes; (b) intracellular parasite cycle; (c) regulation of inflammation and immune response; (d) fibrosis and heart remodeling during acute and chronic disease. All these effects point to an important role of TGF-beta in Chagas disease myocardiopathy and suggest that monitoring the circulating levels of this cytokine could be of help in clinical prognosis and management of patients. Moreover, TGF-beta-interfering therapies appear as interesting adjuvant interventions during acute and chronic phases of T. cruzi infection.
dc.description2022-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectDoença de Chagas
dc.subjectTrypanosoma cruzi
dc.subjectTGF-b
dc.subjectFibrose cardíaca
dc.subjectTGF-b
dc.subjectChagas Disease
dc.subjectTrypanosoma cruzi
dc.subjectCardiac fibrosis
dc.titlePivotal role for TGF-beta in infectious heart disease: The case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy
dc.typeArticle


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