Laminin-Mediated interactions in Thymocyte Migration and Development

dc.creatorSavino, Wilson
dc.creatorCruz, Daniella Arêas Mendes da
dc.creatorGolbert, Daiane Cristina Ferreira
dc.creatorRiederer, Ingo
dc.creatorAlmeida, Vinicius Cotta de
dc.date2016-04-14T16:20:34Z
dc.date2016-04-14T16:20:34Z
dc.date2015
dc.date.accessioned2023-09-26T23:03:33Z
dc.date.available2023-09-26T23:03:33Z
dc.identifierSAVINO, Wilson; et al. Laminin-Mediated Interactions in Thymocyte Migration and Development. Frontiers in Immunology, v.6, Article 579, 13p, Nov. 2015.
dc.identifier1664-3224
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/13776
dc.identifier10.3389/fimmu.2015.00579
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8886362
dc.descriptionIntrathymic T-cell differentiation is a key process for the development and maintenance of cell-mediated immunity, and occurs concomitantly to highly regulated migratory events. We have proposed a multivectorial model for describing intrathymic thymocyte migration. One of the individual vectors comprises interactions mediated by laminins (LMs), a heterotrimeric protein family of the extracellular matrix. Several LMs are expressed in the thymus, being produced by microenvironmental cells, particularly thymic epithelial cells (TECs). Also, thymocytes and epithelial cells express integrin-type LM receptors. Functionally, it has been reported that the dy/dy mutant mouse (lacking the LM isoform 211) exhibits defective thymocyte differentiation. Several data show haptotactic effects of LMs upon thymocytes, as well as their adhesion on TECs; both effects being prevented by anti-LM or anti-LM receptor antibodies. Interestingly, LM synergizes with chemokines to enhance thymocyte migration, whereas classe-3 semaphorins and B ephrins, which exhibit chemorepulsive effects in the thymus, downregulate LM-mediated migratory responses of thymocytes. More recently, we showed that knocking down the ITGA6 gene (which encodes the α6 integrin chain of LM receptors) in human TECs modulates a large number of cell migration-related genes and results in changes of adhesion pattern of thymocytes onto the thymic epithelium. Overall, LM-mediated interactions can be placed at the cross-road of the multivectorial process of thymocyte migration, with a direct influence per se, as well as by modulating other molecular interactions associated with the intrathymic-trafficking events.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectThymus
dc.subjectT-cell development
dc.subjectThymic epithelial cells
dc.subjectExtracellular matrix
dc.subjectLaminin isoforms
dc.subjectIntegrins
dc.subjectChemokines
dc.subjectTimo
dc.subjectCélulas Epiteliais
dc.subjectMatriz Extracelular
dc.subjectLaminina
dc.subjectIsoformas
dc.subjectIntegrinas
dc.subjectQuimiocinas
dc.titleLaminin-Mediated interactions in Thymocyte Migration and Development
dc.typeArticle


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