Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?

dc.creatorRamos, Klaysa Moreira
dc.creatorCastro, Flávia Madeira Monteiro de
dc.creatorLacerda, Leandra Linhares
dc.creatorSavino, Wilson
dc.date2015-12-10T11:23:49Z
dc.date2015-12-10T11:23:49Z
dc.date2011
dc.date.accessioned2023-09-26T23:03:17Z
dc.date.available2023-09-26T23:03:17Z
dc.identifierRAMOS, Klaysa Moreira; et al. Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?. Mem Inst Oswaldo Cruz, v.106, n.6, p.759-762, Sept. 2011.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/12371
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8886311
dc.descriptionThe human T-lymphotropic virus type-1 (HTLV-1) is the cause of adult T cell leukaemias/lymphoma. Because thymic epithelial cells (TEC) express recently defined receptors for the virus, it seemed conceivable that these cells might be a target for HTLV-1 infection. We developed an in vitro co-culture system comprising HTLV-1+-infected T cells and human TECs. Infected T cells did adhere to TECs and, after 24 h, the viral proteins gp46 and p19 were observed in TECs. After incubating TECs with culture supernatants from HTLV-1+-infected T cells, we detected gp46 on TEC membranes and the HTLV-1 tax gene integrated in the TEC genome. In conclusion, the human thymic epithelium can be infected in vitro by HTLV-1, not only via cell-cell contact, but also via exposure to virus-containing medium.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz
dc.rightsopen access
dc.subjectThymic epithelial cells
dc.subjectHTLV-1 infection
dc.subjectAdult T cell leukaemia/lymphoma
dc.subjectCell adhesion
dc.subjectAdesão Celular
dc.subjectCélulas Epiteliais
dc.subjectLeucemia
dc.subjectLinforma
dc.titleCan thymic epithelial cells be infected by human T-lymphotropic virus type 1?
dc.typeArticle


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