Investigation of an outbreak of acute respiratory disease in an indigenous village in Brazil: contribution of Influenza A(H1N1)pdm09 and human respiratory syncytial viruses

dc.creatorCardoso, Andrey Moreira
dc.creatorResende, Paola Cristina
dc.creatorPaixao, Enny S.
dc.creatorTavares, Felipe G.
dc.creatorFarias, Yasmin N.
dc.creatorBarreto, Carla Tatiana G.
dc.creatorPantoja, Lídia N.
dc.creatorFerreira, Fernanda L.
dc.creatorMartins, André Luiz
dc.creatorLima, Ângela Barbosa
dc.creatorFernandes, Daniella A.
dc.creatorSanches, Patrícia Machado
dc.creatorAlmeida, Walquiria A. F.
dc.creatorRodrigues, Laura C.
dc.creatorSiqueira, Marilda Agudo Mendonça Teixeira de
dc.date2019-07-15T17:50:14Z
dc.date2019-07-15T17:50:14Z
dc.date2019
dc.date.accessioned2023-09-26T23:03:14Z
dc.date.available2023-09-26T23:03:14Z
dc.identifierCARDOSO, Andrey Moreira et al. Investigation of an outbreak of acute respiratory disease in an indigenous village in Brazil: contribution of Influenza A(H1N1) pdm09 and human respiratory syncytial viruses. dm09 and human respiratory syncytial viruses. PLoS One, v. 14, n. 7, p. 1-15, July 2019.
dc.identifier1932-6203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/34111
dc.identifier10.1371/journal.pone.0218925
dc.identifier1935-2735
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8886301
dc.descriptionAnalyses of the 2009 H1N1 influenza pandemic and post-pandemic years showed high attack rates and severity among indigenous populations. This study presents the characteristics of the first documented influenza outbreak in indigenous peoples in Brazil, that occurred from 30th March to 14th April 2016 in a Guarani village in Southeast Region. Acute respiratory infections were prospectively investigated. The majority of the 73 cases were influenza-like illness (ILI) (63.0%) or severe acute respiratory infection (SARI) (20.5%). The ILI+SARI attack rate (35.9%) decreased with increasing age. There was a high influenza vaccination rate (86.3%), but no statistically significant difference in vaccination rates between severe and non-severe cases was seen (p = 0.334). Molecular analyses of 19.2% of the cases showed 100% positivity for influenza A(H1N1)pdm09 and/or hRSV. Influenza A(H1N1)pdm09 was included in the 6B.1 genetic group, a distinct cluster with 13 amino acid substitutions of A/California/07/2009-like. The hRSV were clustered in the BA-like genetic group. The early arrival of the influenza season overlapping usual hRSV season, the circulation of a drifted influenza virus not covered by vaccine and the high prevalence of risk factors for infection and severity in the village jointly can explain the high attack rate of ARI, even with a high rate of influenza vaccination. The results reinforce the importance of surveillance of respiratory viruses, timely vaccination and controlling risk factors for infection and severity of in the indigenous populations in order to preventing disease and related deaths, particularly in children.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectInfluenza A (H1N1) pdm09
dc.subjectSurto
dc.subjectDoença respiratória aguda
dc.subjectVírus sincicial respiratório humano
dc.subjectAldeia Indígena
dc.subjectBrasil
dc.subjectInfluenza A(H1N1) pdm09
dc.subjectOutbreak
dc.subjectAcute respiratory disease
dc.subjectHuman respiratory syncytial viruses
dc.subjectindigenous village
dc.subjectBrazil
dc.titleInvestigation of an outbreak of acute respiratory disease in an indigenous village in Brazil: contribution of Influenza A(H1N1)pdm09 and human respiratory syncytial viruses
dc.typeArticle


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