Morphological features of collagen degradation in advanced hepatic schistosomiasis of man.

dc.creatorAndrade, Zilton de Araújo
dc.date2012-10-22T19:17:20Z
dc.date2012-10-22T19:17:20Z
dc.date1992
dc.date.accessioned2023-09-26T23:03:12Z
dc.date.available2023-09-26T23:03:12Z
dc.identifierANDRADE, Z.A. Morphological features of collagen degradation in advanced hepatic schistosomiasis of man. Memórias do Instituto Oswaldo Cruz, v. 87, Suppl 4, p. 129-38, 1992.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5709
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8886294
dc.descriptionOptical and electron microscopical evidences of focal matrix degradation were frequently seen in liver sections taken from patients with periportal ("pipe-stem") fibrosis caused by schistosomiasis mansoni. Besides the presence of focal areas of rarefaction, fragmentation and dispersion of collagen fibers, the enlarged portal spaces also showed hyperplasia of elastic tissue and disarray of smooth muscle fibers following the destruction of portal vein branches. Ultrastructural changes represented by focal lytic and/or electron dense alterations of collagen fibrils were similar to those first seen in experimental material and designated as "chronic collagen degradation". Elastin and related microfibrils were also affected by focal condensation, fragmentation, distortion and dissolution. Schistosome eggs were scanty in the tissue sections examined. Matrix degradation represented involuting changes related to the progressive diminution of parasite aggression, which occurs spontaneously with age or after cure by chemotherapy. Changes of focal matrix degradation now being described represent the basic morphological counterpart of periportal fibrosis involution documented clinically, especially by ultrasonography, in patients with hepatosplenic schistosomiasis submitted to curative chemotherapy.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectHepatic schistosomiasis
dc.subjectCollagen degradation
dc.subjectColágeno/metabolismo
dc.subjectCirrose Hepática/metabolismo
dc.subjectEsquistossomose mansoni/metabolismo
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectCriança
dc.subjectPré-Escolar
dc.subjectTecido Elástico/patologia
dc.subjectMatriz Extracelular/metabolismo
dc.subjectMatriz Extracelular/ultraestrutura
dc.subjectFeminino
dc.subjectHumanos
dc.subjectLactente
dc.subjectCirrose Hepática/parasitologia
dc.subjectCirrose Hepática/patologia
dc.subjectMasculino
dc.subjectMicroscopia Eletrônica
dc.subjectMeia-Idade
dc.subjectMúsculo Liso Vascular/patologia
dc.subjectEsquistossomose mansoni/quimioterapia
dc.subjectEsquistossomose mansoni/patologia
dc.subjectEsquistossomicidas/uso terapêutico
dc.titleMorphological features of collagen degradation in advanced hepatic schistosomiasis of man.
dc.typeArticle


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