Stage-specific immune responses in human Necator americanus infection.

dc.creatorGeiger, Stefan Michael
dc.creatorCaldas, Iramaya Rodrigues
dc.creatorGlone, B. E. M. C.
dc.creatorAzevedo, Ana Carolina Campi
dc.creatorOliveira, Luciana Maria de
dc.creatorBrooker, Simon
dc.creatorDiemert, David
dc.creatorOliveira, Rodrigo Corrêa de
dc.creatorBethony, Jeffrey Michael
dc.date2019-04-23T13:19:10Z
dc.date2019-04-23T13:19:10Z
dc.date2007
dc.date.accessioned2023-09-26T23:03:05Z
dc.date.available2023-09-26T23:03:05Z
dc.identifierGEIGER, Stefan Michael et al. Stage-specific immune responses in human Necator americanus infection. Parasite Immunology, v. 29, n. 7, p. 347-358, 2007.
dc.identifier0141-9838
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/32681
dc.identifier10.1111/j.1365-3024.2007.00950.x
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8886268
dc.descriptionWe describe how hookworms interact with their human hosts by comparing lymphocyte phenotyping, proliferative responses, and cytokine and chemokine secretion patterns in adults who are either mono-infected with Necator americanus or egg-negative controls resident in an area of high transmission in Brazil. Cellular immune responses against crude hookworm antigen extracts from different developmental stages were evaluated simultaneously. Principal component analysis (PCA) was used to reduce the standardized immune responses. Random effects multivariate regression was then used to investigate whether principal components (PC) differ between the two groups once potential confounders and effect modifiers have been accounted for. Although hookworm patients had reduced percentages of T and B cells, they had higher levels of activated CD4(+) T and CD19(+) B cells. This state of 'immune activation' coincided with lower proliferative responses, especially to third-stage larval antigen. Cytokine levels in mono-infected adults were also lower and characterized by a mixed Th1/Th2-type profile. Excretory/secretory antigen from adult worms was a potent modulator of the immune response, resulting in diminished TNF-alpha and IL-10 secretion in peripheral blood mononuclear cells (PBMC) from hookworm infected patients. We propose that the longevity of hookworms in their human hosts results from a stage-specific, down-modulation of the immune response.
dc.description2150-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherBlackwell Publishing
dc.rightsrestricted access
dc.subjectcitocinas
dc.subjectvermes
dc.subjectresposta imune
dc.subjectNecator americanus
dc.subjectCytokines
dc.subjecthookworm
dc.subjectimmune response
dc.subjectNecator americanus
dc.subjectprincipal components analysis
dc.subjectT cells
dc.titleStage-specific immune responses in human Necator americanus infection.
dc.typeArticle


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