Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)

dc.creatorRangel, Alba Lucínia Peixoto
dc.creatorMiller, E Nancy
dc.creatorCastellucci, Léa
dc.creatorJamieson, Sarra E
dc.creatorPeixe, Ricardo Guerra
dc.creatorElias, Liliani de Souza
dc.creatorOliveira, Rodrigo Correa
dc.creatorBahia-Oliveira, Lílian MG
dc.creatorBlackwel, Jenefer M
dc.date2023-05-22T13:02:56Z
dc.date2023-05-22T13:02:56Z
dc.date2009
dc.date.accessioned2023-09-26T23:02:56Z
dc.date.available2023-09-26T23:02:56Z
dc.identifierRANGEL, Alba Lucínia Peixoto et al. Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9). Mem Inst Oswaldo Cruz, v. 104, n. 8, p. 1187-1190, 2009. DOI: 10.1590/S0074-02762009000800019
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/58544
dc.identifier10.1590/S0074-02762009000800019
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8886241
dc.descriptionToxoplasma gondii infection is an important mediator of ocular disease in Brazil more frequently than reported from elsewhere. Infection and pathology are characterized by a strong proinflammatory response which in mice is triggered by interaction of the parasite with the toll-like receptor (TLR)/MyD88 pathway. A powerful way to identify the role of TLRs in humans is to determine whether polymorphisms at these loci influence susceptibility to T. gondii-mediated pathologies. Here we report on a small family-based study (60 families; 68 affected offspring) undertaken in Brazil which was powered for large effect sizes using single nucleotide polymorphisms with minor alleles frequencies > 0.3. Of markers in TLR2, TLR5 and TLR9 that met these criteria, we found an association Family Based Association Tests [(FBAT) Z score = 4.232; p = 1.5 x 10(-5); p(corrected) = 1.2 x 10(-4)] between the C allele (frequency = 0.424; odds ratio = 7; 95% confidence interval 1.6-30.8) of rs352140 at TLR9 and toxoplasmic retinochoroiditis in Brazil. This supports the hypothesis that direct interaction between T. gondii and TLR9 may trigger proinflammatory responses that lead to severe pathologies such as the ocular disease that is associated with this infection in Brazil
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz
dc.rightsopen access
dc.subjecttoxoplasmosis
dc.subjectgenetic polymorphisms
dc.subjecttoll-like receptors
dc.subjecttoxoplasmic retinochoroiditis
dc.subjectBrazil
dc.titleCandidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9)
dc.typeArticle


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