Envolvimento do sistema dopaminérgico na sensibilização comportamental ao femproporex

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorAlcantara, Luciana Mara Alvino
dc.creatorPlaneta, Cleopatra da Silva
dc.creatorDelucia, Roberto
dc.date2014-05-27T11:20:35Z
dc.date2016-10-25T18:18:18Z
dc.date2014-05-27T11:20:35Z
dc.date2016-10-25T18:18:18Z
dc.date2002-12-01
dc.date.accessioned2017-04-06T01:04:30Z
dc.date.available2017-04-06T01:04:30Z
dc.identifierRevista de Ciencias Farmaceuticas, v. 23, n. 1, p. 59-70, 2002.
dc.identifier0101-3793
dc.identifierhttp://hdl.handle.net/11449/67138
dc.identifierhttp://acervodigital.unesp.br/handle/11449/67138
dc.identifier2-s2.0-0037936607
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/888623
dc.descriptionThe effects of repeated administration of fenproporex (FEN) on motor activity of rats were studied. FEN-treated group (5.0 mg/kg, i.p., single dose, 7 consecutive days), showed a marked increase in the motor activity of rats, indicating that the drug induced behavioral sensitization. Repeated coadministration of haloperidol prevented the development of sensitization to repeated administration of FEN. Repeated administration of FEN increased also locomotor activity measured in the open field, ratifying the occurence of sensitization. These findings indicated development of sensitization to repeated FEN administration and that the dopamine system might be involved in the mechanism of sensitization.
dc.languagepor
dc.relationRevista de Ciencias Farmaceuticas
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBehavioral sensitization
dc.subjectDopamine system
dc.subjectFenproporex
dc.subjectfenproporex
dc.subjecthaloperidol
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectbehavior modification
dc.subjectcontrolled study
dc.subjectdopamine release
dc.subjectdose time effect relation
dc.subjectdrug inhibition
dc.subjectdrug mechanism
dc.subjectdrug sensitization
dc.subjectlocomotion
dc.subjectmotor activity
dc.subjectnonhuman
dc.subjectopen field behavior
dc.subjectrat
dc.subjectsingle drug dose
dc.titleEnvolvimento do sistema dopaminérgico na sensibilização comportamental ao femproporex
dc.typeOtro


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