Withalutin, a new cytotoxic withanolide from Athenaea velutina (Sendtn.) D'Arcy

dc.creatorAlmeida, Alisson Andrade
dc.creatorCota, Betania Barros
dc.creatorRodrigues, Laís A.
dc.creatorDutra, Luana L.
dc.creatorKohlhoff, Markus
dc.creatorBressan, Gustavo C.
dc.creatorBrandão, Geraldo Celio
dc.creatorLeite, João P. V.
dc.date2022-11-21T17:58:26Z
dc.date2022-11-21T17:58:26Z
dc.date2022
dc.date.accessioned2023-09-26T23:02:54Z
dc.date.available2023-09-26T23:02:54Z
dc.identifierALMEIDA, Alisson Andrade et al. Withalutin, a new cytotoxic withanolide from Athenaea velutina (Sendtn.) D'Arcy. Natural Product Research, v. 2022, p. 1-8, 2022.
dc.identifier1478-6419
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/55742
dc.identifier10.1080/14786419.2022.2039135
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8886236
dc.descriptionBioassay-guided fractionation of dichloromethane extract from Athenaea velutina leaves led to the isolation of three withanolides, all being reported for the first time in this species. They were identified as withacnistin (1), withacnistin acetate (2) and a new withanolide, designated as withalutin (3). The structures were established by spectral data analysis, including MS, 1D and 2D NMR. In addition, in silico ADMET studies were employed to understand the pharmacokinetic properties of these withanolides. The withanolides isolated from A. velutina reduced cancer cell viability with IC50 values ranging from 1.52 to 5.39 µM. In silico prediction revealed that withanolides have good gastrointestinal absorption or oral bioavailability properties; and are not likely to be mutagenic or hepatotoxic. These findings revealed that A. velutina is an important source of cytotoxic withanolides.
dc.description2097
dc.formatapplication/pdf
dc.languageeng
dc.publisherTaylor & Francis Health Sciences
dc.rightsrestricted access
dc.subjectAthenaea velutina
dc.subjectCytotoxic activities
dc.subjectIn silico ADMET analysis
dc.subjectWithalutin
dc.subjectWithanolides
dc.titleWithalutin, a new cytotoxic withanolide from Athenaea velutina (Sendtn.) D'Arcy
dc.typeArticle


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