Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTM1) and theta (GSTT1) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis?

dc.creatorArruda, Valder Roberval
dc.creatorGrignolli, Carlos E
dc.creatorGonçalves, Marilda de Souza
dc.creatorSoares, Manoel C
dc.creatorMenezes, Raimundo
dc.creatorSaad, Sara Teresinha Ollala
dc.creatorCosta, Fernando Ferreira
dc.date2017-06-07T16:07:29Z
dc.date2017-06-07T16:07:29Z
dc.date1998
dc.date.accessioned2023-09-26T23:02:33Z
dc.date.available2023-09-26T23:02:33Z
dc.identifierARRUDA, V. R. et al. Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTM1) and theta (GSTT1) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis? Clinical Genetics, v. 54, n. 3, p. 210-214, 1998.
dc.identifier0009-9163
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/19338
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8886165
dc.descriptionMarilda de Souza Gonçalves “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
dc.descriptionEnvironmental related diseases due to occupational carcinogens and toxic substances are a serious problem particularly in developing countries. The glutathione S-transferase system is fundamental for the detoxification of numerous carcinogens and mutagens. The individual inherited susceptibility to chemical carcinogenesis due to glutathione S-transferase mu (GSTMl) and theta (GSTTl) varies significantly among distinct ethnic groups. In this study we determined the prevalence of the null genotype of the GSTMl and GSTTl genes among individuals from three distinct Brazilian racial groups using a multiplex- PCR methodology. The results showed that the highest prevalence of the null genotype for the GSTMl occurred among Caucasians (55%, allele frequency = 0.74), followed by 33% among Brazilian Black subjects (allele frequency = 0.57). and 20% among Amazonian Indians (allele frequency = 0.45). For GSTTl a homogenous distribution of the null genotype was found among Caucasian and African descendants (18.5 and 19% homozygotes, respectively, allele. frequency = 0.43). with a lower prevalence among Amazonian Indians (1 1% of homozygotes, a!lele frequency = 0.34). Whether the deficiency of the GST system contributes to a predisposition to environmental related carcinogenesis in I specific popuiations in Brazil remains to be determined.
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsopen access
dc.subjectDNA
dc.subjectGlutationa S transferase
dc.subjectPCR
dc.subjectMutação
dc.subjectDNA analysls
dc.subjectGlutathione S transferase mu
dc.subjectGlutathione S transferase mu theta gene
dc.subjectPCR
dc.subjectMutation
dc.subjectDNA
dc.subjectGlutationa S transferase
dc.subjectPCR
dc.subjectCarcinogênese
dc.subjectMutação
dc.titlePrevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTM1) and theta (GSTT1) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis?
dc.typeArticle


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