dc.creator | Silva, Eufrânio N. da | |
dc.creator | Guimarães, Tiago T. | |
dc.creator | Menna-Barreto, Rubem F. S. | |
dc.creator | Pinto, Maria do Carmo F. R. | |
dc.creator | Simone, Carlos A. de | |
dc.creator | Pessoa, Claudia | |
dc.creator | Cavalcanti, Bruno C. | |
dc.creator | Sabino, José R. | |
dc.creator | Andrade, Carlos Kleber Z. | |
dc.creator | Goulart, Marilia O. F. | |
dc.creator | Castro, Solange L. de | |
dc.creator | Pinto, Antônio V. | |
dc.date | 2018-11-29T14:22:28Z | |
dc.date | 2018-11-29T14:22:28Z | |
dc.date | 2010 | |
dc.date.accessioned | 2023-09-26T23:01:34Z | |
dc.date.available | 2023-09-26T23:01:34Z | |
dc.identifier | SILVA JÚNIOR, Eufrânio N. da; et al. The evaluation of quinonoid compounds against Trypanosoma cruzi: Synthesis of imidazolic anthraquinones, nor-b-lapachone derivatives and b-lapachone-based 1,2,3-triazoles. Bioorganic & Medicinal Chemistry, v.18, p.3224–3230, 2010. | |
dc.identifier | 0968-0896 | |
dc.identifier | https://www.arca.fiocruz.br/handle/icict/30319 | |
dc.identifier | 10.1016/j.bmc.2010.03.029 | |
dc.identifier | 1464-3391 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8885981 | |
dc.description | In continuing our screening program of naphthoquinone activity against Trypanosoma cruzi, the aetiological agent of Chagas' disease, new beta-lapachone-based 1,2,3-triazoles, 3-arylamino-nor-beta-lapachones, 3-alkoxy-nor-beta-lapachones and imidazole anthraquinones were synthesised and evaluated against bloodstream trypomastigote forms of the parasite. Compounds 2,2-dimethyl-3-(2,4-dibromophenylamino)-2,3-dihydro-naphtho[1,2-b]furan-4,5-dione, IC(50)/24h 24.9+/-7.4 and 4-azido-3-bromo-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione with 23.4+/-3.8 microM showed a trypanosomicidal activity higher than benznidazole. These results demonstrate the potential of naphthoquinone derivatives as novel structures for the development of alternative drugs for Chagas' disease. | |
dc.description | 2030-01-01 | |
dc.format | application/pdf | |
dc.language | eng | |
dc.publisher | Elsevier | |
dc.rights | restricted access | |
dc.subject | Doença de Chagas | |
dc.subject | Trypanosoma cruzi | |
dc.subject | Quimioterapia experimental | |
dc.subject | Naftoquinonas | |
dc.subject | Naphthoquinones | |
dc.subject | Nor-b-lapachone | |
dc.subject | Chagas Disease | |
dc.subject | Trypanosoma cruzi | |
dc.subject | Experimental chemotherapy | |
dc.subject | Naftoquinonas | |
dc.title | The evaluation of quinonoid compounds against Trypanosoma cruzi: synthesis of imidazolic anthraquinones, nor-beta-lapachone derivatives and beta-lapachone-based 1,2,3-triazoles | |
dc.type | Article | |