Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil

dc.creatorSantana, Nelma Pereira de
dc.creatorFreitas, Luiz Antonio Rodrigues de
dc.creatorLyra, André de Castro
dc.creatorParaná, Raymundo
dc.creatorSantana, Genoile
dc.creatorTrépo, Christian
dc.creatorLyra, Luiz Guilherme Costa
dc.date2013-01-18T19:42:20Z
dc.date2013-01-18T19:42:20Z
dc.date2005
dc.date.accessioned2023-09-26T23:01:04Z
dc.date.available2023-09-26T23:01:04Z
dc.identifierSANTANA, N. P. de et al. Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil. Brazilian Journal of Infectious Diseases, v. 9, n. 2, p. 134-141, apr. 2005.
dc.identifier1413-8670
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/6215
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8885883
dc.descriptionPatients with chronic hepatitis C can have variable clinical progression. Hepatic histological alterations appear to be milder in asymptomatic subjects who have persistently normal ALT levels. Aims: To evaluate the severity of histological liver alterations in blood donors with normal and elevated ALT levels. Methods: We evaluated volunteer blood donors from the main blood bank of the city of Salvador-Brazil. Those who were anti-HCV positive were invited to participate in the study. Serum ALT and AST levels were measured at two time points, two months apart. Donors were divided into two groups: group I, individuals with ALT ≥ 1.5 times the upper limit of normal in at least one time point and group II, individuals with normal or near normal ALT, at both time points. Results: We evaluated 30,232 blood donors and 528 (1.7%) of them were anti-HCV positive. Eighty-two attended our service and HCV infection was confirmed in 66 individuals. Male gender predominated in both groups; the mean age was 36 for group I, and 33 for group II. Tattoos and intravenous illicit drug use were frequently-encountered risk factors. Liver biopsy was done in 43 subjects. Among donors with elevated ALT, two (10%) had minimum alterations, while in group II normal liver or minimum alterations were observed in six (26%) subjects. Chronic hepatitis or cirrhosis was encountered in 35 (81%) individuals: three (15%) and five (21%) subjects had chronic hepatitis without inflammatory activity, 10 (50%) and 11 (48%) had minimum to moderate activity and five (25%) and one (4.3%) had cirrhosis, in groups I and II, respectively (P was not significant). Conclusions: The prevalence of anti-HCV among this population of volunteer blood donors was 1.7%, and these subjects had few liver histological alterations or chronic hepatitis and cirrhosis. Liver injury severity was significant in patients with elevated ALT, however subjects with normal levels may also present chronic hepatitis and cirrhosis.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectALT levels
dc.subjectLiver alterations
dc.subjectHCV
dc.subjectNortheast-Brazil
dc.subjectAlanina Transaminase/sangue
dc.subjectAspartato Aminotransferases/sangue
dc.subjectHepacivirus/imunologia
dc.subjectHepatite C Crônica/patologia
dc.subjectFígado/patologia
dc.subjectDoadores de Sangue
dc.subjectBrasil/epidemiologia
dc.subjectEnsaio de Imunoadsorção Enzimática
dc.subjectAnticorpos Anti-Hepatite C/sangue
dc.subjectHepatite C Crônica/enzimologia
dc.subjectHepatite C Crônica/epidemiologia
dc.subjectFatores de Risco
dc.subjectÍndice de Gravidade de Doença
dc.subjectFeminino
dc.subjectHumanos
dc.subjectMasculino
dc.titleLiver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil
dc.typeArticle


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