Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms

dc.creatorCampos, Cecilia Bonolo de
dc.creatorDamasceno, Karine Araujo
dc.creatorGamba, Conrado de Oliveira
dc.creatorRibeiro, Ana M
dc.creatorMachado, Carla Jorge
dc.creatorLavalle, Gleidice Eunice
dc.creatorCassali, Geovanni Dantas
dc.date2018-02-27T14:33:36Z
dc.date2018-02-27T14:33:36Z
dc.date2016
dc.date.accessioned2023-09-26T23:00:30Z
dc.date.available2023-09-26T23:00:30Z
dc.identifierCAMPOS, C. B. et al. Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms. Journal of Feline Medicine and Surgery, v. 18, n. 12, p. 1003–1012, 2016.
dc.identifier1098-612X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/24968
dc.identifier10.1177/1098612X15610367
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8885792
dc.descriptionDAMASCENO, Karine Araújo. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Coordenacão de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento e Pesquisa (CNPq) and Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG).
dc.descriptionThe aim of the study was to investigate prognostic factors in feline mammary gland neoplasms, correlating them with overall survival (OS). Objectives The aim of the study was to investigate prognostic factors in feline mammary gland neoplasms, correlating them with overall survival (OS). Methods Fifty-six primary malignant mammary gland neoplasms and 16 metastatic lymph nodes from 37 female cats were analyzed. Clinical staging, histologic type and grade, and immunohistochemistry for Ki-67, progesterone and estrogen receptor, human epidermal growth factor receptor type 2 (HER-2), cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) were evaluated. Follow-up was performed in order to correlate prognostic factors with OS. Results Lymph node metastasis was found in 35% of cases. Clinical stage III, tubulopapillary carcinomas and histologic grade II cases prevailed in the study. Most neoplasms were positive for hormonal receptors, negative for HER-2 overexpression and presented VEGF overexpression. Immunoreactivity for Ki-67 (P = 0.046) and COX-2 (P = 0.007) was higher in metastases than in primary tumors. COX-2 (P = 0.089), HER-2 (P = 0.012) and histologic grade (P = 0.080) were correlated with OS. Conclusions and relevance The data suggest that inhibition of ovarian hormones and COX-2 may represent a therapeutic option for malignant feline mammary gland neoplasms. When evaluating disease progression, COX-2 scores and Ki-67 index should be analyzed in primary tumors and metastases. histologic grade, HER-2 status and COX-2 scores were found to have a direct influence on OS. Prognostic factors allow for a better understanding of disease outcome in a condition that is characterized by a poor prognosis. The present work highlights the need for further studies on endocrine therapy and COX-2 inhibitors, which could influence OS.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSAGE Publications
dc.rightsopen access
dc.subjectNeoplasia maligna
dc.subjectNeoplasias mamárias
dc.subjectMetástase linfática
dc.subjectPrognostico
dc.subjectAnimais
dc.subjectMalignant neoplasms
dc.subjectBreast neoplasm
dc.subjectLymphatic Metastasis
dc.subjectPrognosis
dc.subjectAnimals
dc.titleEvaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms
dc.typeArticle


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