Histoarchitecture of schistosomal granuloma development and involution: morphogenetic and biomechanical approaches

dc.creatorLenzi, Henrique L.
dc.creatorKimmel, Eitan
dc.creatorSchechtman, Helio
dc.creatorMachado, Marcelo Pelajo
dc.creatorRomanha, Waldemiro S.
dc.creatorPacheco, Ronaldo G.
dc.creatorMariano, Mario
dc.creatorLenzi, Jane A.
dc.date2019-11-12T10:44:15Z
dc.date2019-11-12T10:44:15Z
dc.date1998
dc.date.accessioned2023-09-26T23:00:18Z
dc.date.available2023-09-26T23:00:18Z
dc.identifierLENZI, Henrique L. et al. Histoarchitecture of Schistosomal Granuloma Development and Involution: Morphogenetic and Biomechanical Approaches. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 93, Suppl. 1, p. 141-151, 1998.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/36986
dc.identifier10.1590/s0074-02761998000700020
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8885753
dc.descriptionThe authors present morphogenetic and biomechanical approaches on the concept of the Schistosoma mansoni granulomas, considering them as organoid structures that depend on cellular adhesion and sorting, forming rearrangement into hierarchical concentric layers, creating tension-dependent structures, aiming to acquire round form, since this is the minimal energy form, in which opposing forces pull in equally from all directions and are in balance. From the morphogenetic point of view, the granulomas function as little organs, presenting maturative and involutional stages in their development with final disappearance (pre-granulomatous stages, subdivided in: weakly and/or initial reactive and exudative; granulomatous stages: exudative-productive, productive and involutional). A model for the development of granulomas was suggested, according to the following stages: encapsulating, focal histolysis, fiber production, orientation and compacting and involution and disintegration. The authors concluded that schistosomal granuloma is not a tangled web of individual cells and fibers, but an organized structure composed by host and parasite components, which is not formed to attack the miracidia, but functions as an hybrid interface between two different phylogenetic beings.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.rightsopen access
dc.subjectSchistosoma mansoni
dc.subjectGranuloma
dc.subjectBiomecânica
dc.subjectFibrose
dc.subjectMatriz extracelular
dc.subjectMicroscopia confocal a laser
dc.subjectSchistosoma mansoni
dc.subjectGranuloma
dc.subjectBiomechanics
dc.subjectFibrosis
dc.subjectExtracellular matrix
dc.subjectLaser confocal microscopy
dc.titleHistoarchitecture of schistosomal granuloma development and involution: morphogenetic and biomechanical approaches
dc.typeArticle


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