Neutrophils in leprosy

dc.creatorSchmitz, Veronica
dc.creatorTavares, Isabella Forasteiro
dc.creatorPignataro, Patricia
dc.creatorMachado, Alice de Miranda
dc.creatorPacheco, Fabiana dos Santos
dc.creatorSantos, Jéssica Brandão dos
dc.creatorSilva, Camila Oliveira da
dc.creatorSarno, Euzenir Nunes
dc.date2019-07-12T17:30:33Z
dc.date2019-07-12T17:30:33Z
dc.date2019
dc.date.accessioned2023-09-26T22:59:59Z
dc.date.available2023-09-26T22:59:59Z
dc.identifierSCHMITZ, Veronica et al. Neutrophils in Leprosy. Frontiers in Immunology, v. 10, p. 1-10, Mar. 2019.
dc.identifier1664-3224
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/34034
dc.identifier10.3389/fimmu.2019.00495
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8885691
dc.descriptionLeprosyisaninfectiousdiseasecausedbytheintracellularbacillusMycobacteriumleprae that mainly affects the skin and peripheral nerves. One of the most intriguing aspects of leprosy is the diversity of its clinical forms. Paucibacillary patients are characterized as having less than five skin lesions and rare bacilli while the lesions in multibacillary patients are disseminated with voluminous bacilli. The chronic course of leprosy is often interrupted by acute episodes of an inflammatory immunological response classified as either reversal reaction or erythema nodosum leprosum (ENL). Although ENL is considered a neutrophilic immune-complex mediated condition, little is known about the direct role of neutrophils in ENL and leprosy disease overall. Recent studies have shown a renewed interest in neutrophilic biology. One of the most interesting recent discoveries was that the neutrophilic population is not homogeneous. Neutrophilic polarization leads to divergent phenotypes (e.g., a pro- and antitumor profile) that are dynamic subpopulations with distinct phenotypical and functional abilities. Moreover, there is emerging evidence indicating that neutrophils expressing CD64 favor systemic inflammation during ENL. In the present review, neutrophilic involvement in leprosy is discussed with a particular focus on ENL and the potential of neutrophils as clinical biomarkers and therapeutic targets.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectHanseníase
dc.subjectMycobacterium leprae
dc.subjectInflamação
dc.subjectNeutrófilos
dc.subjectEritema nodoso hansênico
dc.subjectLeprosy
dc.subjectMycobacterium leprae
dc.subjectErythema nodosum leprosum
dc.subjectInflammation
dc.subjectNeutrophils
dc.titleNeutrophils in leprosy
dc.typeArticle


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