Ocular toxoplasmosis in mice: comparison of two routes of infection

dc.creatorTedesco, R. C.
dc.creatorSmith, R. L.
dc.creatorCorte-Real, Suzana
dc.creatorCalabrese, K. S.
dc.date2019-12-17T11:45:24Z
dc.date2019-12-17T11:45:24Z
dc.date2005
dc.date.accessioned2023-09-26T22:59:46Z
dc.date.available2023-09-26T22:59:46Z
dc.identifierTEDESCO, R. C. et al. Ocular toxoplasmosis in mice: comparison of two routes of infection. Parasitology, v. 131, p. 303-307, 2005.
dc.identifier0031-1820
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/38061
dc.identifier10.1017/s003118200500781x
dc.identifier1469-8161
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8885651
dc.descriptionThis paper aims to test the influence of route of infection (intravitreal and instillation) on the course of ocular toxoplasmosis in mice, using the Toxoplasma gondii Me-49 strain. All mice inoculated intravitreally or by instillation presented the same pattern of infection. Using either route, parasites were observed in the retinal vessel with the formation of a glial reaction in the inner plexiforme layer and discontinuity of the pigmented epithelium of the retina 7 days after infection. However, when the intravitreal route was used a more intense inflammatory infiltrate was observed in the retina. The results suggest that inoculation route remarkably influences the inflammatory pattern in ocular toxoplasmosis and that the instillation route should be preferentially used in experimental infections in the murine ocular model of infection by T. gondii, specially with small animals where there is extensive needle damage, which is not observed in the instillation route.
dc.description2022-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherCambridge University Press
dc.rightsrestricted access
dc.subjectToxoplasma gondii
dc.subjectToxoplasmose Ocular
dc.subjectInstilação
dc.subjectCamundongos
dc.subjectToxoplasma gondii
dc.subjectOcular toxoplasmosis
dc.subjectIntravitreal
dc.subjectInstillation
dc.subjectMouse model
dc.titleOcular toxoplasmosis in mice: comparison of two routes of infection
dc.typeArticle


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