Efeito de drogas utilizadas no tratamento de hipertensão arterial sistêmica sobre a pressão intra-ocular: Estudo experimental no cão

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorHashimoto, Mitsuo
dc.creatorDe Moraes Silva, Maria Rosa Bet
dc.creatorTeixeira Neto, Francisco José
dc.date2014-05-27T11:20:33Z
dc.date2016-10-25T18:18:09Z
dc.date2014-05-27T11:20:33Z
dc.date2016-10-25T18:18:09Z
dc.date2002-12-01
dc.date.accessioned2017-04-06T01:03:54Z
dc.date.available2017-04-06T01:03:54Z
dc.identifierArquivos Brasileiros de Oftalmologia, v. 65, n. 2, p. 229-233, 2002.
dc.identifier0004-2749
dc.identifierhttp://hdl.handle.net/11449/67065
dc.identifierhttp://acervodigital.unesp.br/handle/11449/67065
dc.identifier10.1590/S0004-27492002000200013
dc.identifierS0004-27492002000200013
dc.identifier2-s2.0-52649173307.pdf
dc.identifier2-s2.0-52649173307
dc.identifierhttp://dx.doi.org/10.1590/S0004-27492002000200013
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/888556
dc.descriptionPurpose: To study the effects of two drugs (captopril and propranolol) used in the treatment of systemic hypertension, on the intraocular pressure (IOP) of anesthetized dogs. Methods: 24 dogs, divided into 3 groups of 8 each. In the first group, 1.5 mg/kg IV of captopril (an angiotensin converting enzyme inhibitor) was administered. In the second group, 1.5 mg/kg IV of propranolol (a beta-blocker) was administered. The third group was the control. IOP and blood pressure (BP) were measured by manometry. The perfusion pressure was calculated by the difference between BP and IOP (BP-IOP). The parameters were studied at 6 moments (0, 10, 30, 60, 90 and 120 minutes). Results: There was significant reduction of IOP (p<0.05) with captopril and propranolol, without difference between the drugs. With captopril the BP and PP decreased markedly at 10 and 30 minutes. With propranolol there was no reduction of BP or PP. Conclusions: Captopril and propranolol reduced IOP. However, the marked reduction of BP, and consequently of PP caused by captopril may be undesirable for irrigation of the optic nerve.
dc.languagepor
dc.relationArquivos Brasileiros de Oftalmologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCaptopril/therapeutic use
dc.subjectDogs
dc.subjectGlaucoma
dc.subjectHypertension/drug therapy
dc.subjectIntraocular pressure/drug effects
dc.subjectPropranolol/therapeutic use
dc.titleEfeito de drogas utilizadas no tratamento de hipertensão arterial sistêmica sobre a pressão intra-ocular: Estudo experimental no cão
dc.typeOtro


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