Chagas Disease Predicts 10-Year Stroke Mortality in Community-Dwelling Elderly The Bambuí Cohort Study of Aging

dc.creatorCosta, Maria Fernanda Lima
dc.creatorMatos, Divane Leite
dc.creatorRibeiro, Antonio Luiz P.
dc.date2013-06-03T19:25:34Z
dc.date2013-06-03T19:25:34Z
dc.date2010
dc.date.accessioned2023-09-26T22:58:06Z
dc.date.available2023-09-26T22:58:06Z
dc.identifierLIMA COSTA, Maria Fernanda; MATOS, Divane Leite; RIBEIRO, Antonio Luiz. Chagas disease predicts 10-year stroke mortality in community-dwelling elderly (The Bambuí Cohort Study of Aging). Stroke, v. 145, p. 2477-2482, Nov. 2010.
dc.identifier1524-4628
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/6548
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8885320
dc.descriptionBackground and Purpose—Previous case– control studies have suggested a causal link between Chagas disease, which is caused by the protozoan Trypanosoma cruzi, and stroke. We investigated the relationship between Chagas disease and long-term stroke mortality in a large community-based cohort of older adults. Methods—Participants were 1398 (80.3% from total) residents aged _60 years in Bambuí City, Brazil. The end point was death from stroke. Potential confounding variables included age, sex, conventional stroke risk factors, and high sensitive C-reactive protein. Results—Participants of this study were followed from 1997 to 2007 leading to 9740 person-years of observation. The baseline prevalence of T. cruzi infection was 37.5% and the overall mortality rate from stroke was 4.62 per 1000 person-years. The risk of death from stroke among T. cruzi-infected participants was twice that of those noninfected (adjusted hazard ratio, 2.36; 95% CI, 1.25 to 4.44). A B-type natriuretic peptide level in the top quartile was a strong and independent predictor of stroke mortality among those infected (adjusted hazard ratio, 2.72; 95% CI, 1.25 to 5.91). The presence of both a high B-type natriuretic peptide level and electrocardiographic atrial fibrillation increased the risk of stroke mortality by 11.49 (95% CI, 3.19 to 41.38) in these individuals. Conclusions—This study provides new evidence supporting a causal link between Chagas disease and stroke. The results also showed that B-type natriuretic peptide alone or in association with atrial fibrillation has prognostic value for stroke mortality in T. cruzi chronically infected older adults
dc.formatapplication/pdf
dc.languagepor
dc.publisherAmerican Heart Association
dc.rightsopen access
dc.subjectBrain natriuretic peptide
dc.subjectStroke mortality
dc.subjectEpidemiology
dc.subjectEtiology
dc.subjectChagas disease
dc.subjectTrypanosoma Cruzi
dc.titleChagas Disease Predicts 10-Year Stroke Mortality in Community-Dwelling Elderly The Bambuí Cohort Study of Aging
dc.typeArticle


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