Calibration and validation of the pneumonia shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study

dc.creatorCarmo, Thomas A
dc.creatorFerreira, Isabella B B
dc.creatorMenezes, Rodrigo C
dc.creatorPina, Márcio L T
dc.creatorOliveira, Roberto S
dc.creatorTelles, Gabriel P
dc.creatorMachado, Antônio F A
dc.creatorAguiar, Tércio C
dc.creatorCaldas, Juliana R
dc.creatorArriaga, María B
dc.creatorAkrami, Kevan M
dc.creatorFilgueiras Filho, Nivaldo M
dc.creatorAndrade, Bruno B
dc.date2022-09-23T17:44:41Z
dc.date2022-09-23T17:44:41Z
dc.date2022
dc.date.accessioned2023-09-26T22:57:53Z
dc.date.available2023-09-26T22:57:53Z
dc.identifierCARMO, Thomas A. et al. Calibration and validation of the Pneumonia Shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study. Frontiers in Medicine, n. 9, p. 1-8, 2022.
dc.identifier2296-858X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/54856
dc.identifier10.3389/fmed.2022.958291
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8885275
dc.descriptionIntramural Research Programa da Fundação Oswaldo Cruz, Brasil. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Fogarty International Center and National Institute of Child Health and Human Development of the National Institutes of Health. Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).
dc.descriptionBackground: Prognostic tools developed to stratify critically ill patients in Intensive Care Units (ICUs), are critical to predict those with higher risk of mortality in the first hours of admission. This study aims to evaluate the performance of the pShock score in critically ill patients admitted to the ICU with SARS-CoV-2 infection. Methods: Prospective observational analytical cohort study conducted between January 2020 and March 2021 in four general ICUs in Salvador, Brazil. Descriptive statistics were used to characterize the cohort and a logistic regression, followed by cross-validation, were performed to calibrate the score. A ROC curve analysis was used to assess accuracy of the models analyzed. Results: Six hundred five adult ICU patients were included in the study. The median age was 63 (IQR: 49-74) years with a mortality rate of 33.2% (201 patients). The calibrated pShock-CoV score performed well in prediction of ICU mortality (AUC of 0.80 [95% Confidence Interval (CI): 0.77-0.83; p-value < 0.0001]). Conclusions: The pShock-CoV score demonstrated robust discriminatory capacity and may assist in targeting scarce ICU resources during the COVID-19 pandemic to those critically ill patients most likely to benefit.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectCritical Care
dc.subjectPrognosis
dc.subjectCOVID-19
dc.subjectMortality
dc.subjectRisk factors
dc.subjectCuidados intensivos
dc.subjectPrognóstico
dc.subjectCOVID-19
dc.subjectFatores de risco
dc.subjectMortalidade
dc.subjectFatores de risco
dc.subjectCritical care
dc.subjectPrognosis
dc.subjectCOVID-19
dc.subjectMortality
dc.subjectRisk factors
dc.subjectCuidados Críticos
dc.subjectPrognóstico
dc.subjectCOVID-19
dc.subjectMortalidade
dc.subjectFatores de Risco
dc.titleCalibration and validation of the pneumonia shock Score in critically ill patients with SARS-CoV-2 infection, a multicenter prospective cohort study
dc.typeArticle


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