Trypanosoma cruzi and myoid cells from seminiferous tubules: interaction and relation with fibrous components of extracellular matrix in experimental Chagas' disease

dc.creatorCarvalho, Luiz Otávio Pereira
dc.creatorSilva, Ana Lucia Abreu
dc.creatorHardoim, Daiana de Jesús
dc.creatorTedesco, Roberto Carlos
dc.creatorMendes, Verônica Gonçalves
dc.creatorCosta, Sylvio Celso Gonçalves da
dc.creatorCalabrese, Kátia da Silva
dc.date2018-12-27T12:42:19Z
dc.date2018-12-27T12:42:19Z
dc.date2009
dc.date.accessioned2023-09-26T22:57:50Z
dc.date.available2023-09-26T22:57:50Z
dc.identifierCARVALHO, Luiz Otávio Pereira; et al. Trypanosoma cruzi and myoid cells from seminiferous tubules: interaction and relation with fibrous components of extracellular matrix in experimental Chagas’ disease. Int. J. Exp. Path., v.90, p.52-57, 2009.
dc.identifier0959-9673
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/30787
dc.identifier10.1111/j.1365-2613.2008.00592.x
dc.identifier1365-2613
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8885268
dc.descriptionThe main transmission route of Trypanosoma cruzi is by triatomine bugs. However, T. cruzi is also transmitted through blood transfusion, organ transplantation, ingestion of contaminated food or fluids, or is congenital. Sexual transmission, although suggested since the discovery of Chagas' disease, has remained unproven. Sexual transmission would require T. cruzi to be located at the testes and ovaries. Here we investigated whether T. cruzi is present in the gonads of mice infected with 10(4) T. cruzi trypomastigotes from the CL strain. Fourteen days after experimental infection, histopathological examination showed alterations in the extracellular matrix of the lamina propria of the seminiferous tubules. Furthermore, amastigotes were present in seminiferous tubules, within myoid cells, and in the adjacencies of the basal compartment. These results indicate that T. cruzi is able to reach seminiferous tubule lumen, thus suggesting that Chagas' disease could potentially be transmitted through sexual intercourse. Complementary studies are required to demonstrate that Chagas' disease can be transmitted by coitus.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsrestricted access
dc.subjectDoença de Chagas
dc.subjectMatriz Extracelular
dc.subjectColágeno
dc.subjectTúbulos Seminíferos
dc.subjectcélulas mióides
dc.subjectDoença de Chagas experimental
dc.subjectcollagenous
dc.subjectexperimental Chagas Disease
dc.subjectextracellular matrix
dc.subjectmyoid cells
dc.subjectseminiferous tubules
dc.subjectTúbulos Seminíferos
dc.titleTrypanosoma cruzi and myoid cells from seminiferous tubules: interaction and relation with fibrous components of extracellular matrix in experimental Chagas' disease
dc.typeArticle


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