Prevalence of oral hairy leukoplakia and epithelial infection by Epstein-Barr virus in pregnant women and diabetes mellitus patients--cytopathologic and molecular study

dc.creatorMilagres, Adrianna
dc.creatorDias, Eliane Pedra
dc.creatorTavares, Débora dos Santos
dc.creatorCavalcante, Roberta Miranda
dc.creatorDantas, Vivian Antunes
dc.creatorOliveira, Silvia Paula de
dc.creatorLeite, José Paulo Gagliardi
dc.date2019-10-22T11:31:38Z
dc.date2019-10-22T11:31:38Z
dc.date2007
dc.date.accessioned2023-09-26T22:56:48Z
dc.date.available2023-09-26T22:56:48Z
dc.identifierMILAGRES, Adrianna et al. Prevalence of oral hairy leukoplakia and epithelial infection by Epstein- Barr virus in pregnant women and diabetes mellitus patients – cytopathologic and molecular study. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 2, p. 159-164, Mar. 2007.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/36616
dc.identifier10.1590/s0074-02762007005000017
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8885077
dc.descriptionOral hairy leukoplakia (OHL) is generally reported in patients with severe immunosuppression, except for a few cases in individuals with moderate degree of immunodeficiency. It is a white lesion that appears mainly in the lateral border of the tongue, caused by Epstein-Barr virus (EBV). The nuclear changes caused by EBV (Cowdry A inclusion, ground glass and nuclear beading), observed in cytopathology, are specific and enough for the definitive diagnosis of OHL, independent of the identification of the virus. Here we investigated the prevalence of OHL and the presence of EBV-DNA in the lateral borders of the tongue from 90 pregnant women, 90 diabetes mellitus (DM) patients, 30 healthy individuals (negative group) and 30 HIV+ with OHL (positive group). Smears were analyzed by cytopathology and polymerase chain reaction (PCR). A case of subclinical OHL and candidiasis was identificated in a DM patient by cytopathologic analysis. PCR results demonstrated EBV-DNA in 65% of the pregnant women, in 35% of DM patients, and in 20% of the healthy individuals. We concluded that DM patients can develop OHL with a low prevalence. Furthermore, the prevalence of the EBV in lateral border of the tongue is larger in pregnant women than in healthy individuals.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.rightsopen access
dc.subjectGestantes
dc.subjectDiabetes mellitus
dc.subjectCitopatologia
dc.subjectReação em Cadeia da Polimerase
dc.subjectOral hairy leukoplakia
dc.subjectPregnant
dc.subjectDiabetes mellitus
dc.subjectEpstein-Barr virus
dc.subjectCytopathology
dc.subjectPolymerase chain reaction
dc.subjectLeucoplasia Pilosa
dc.subjectReação em Cadeia da Polimerase
dc.titlePrevalence of oral hairy leukoplakia and epithelial infection by Epstein-Barr virus in pregnant women and diabetes mellitus patients--cytopathologic and molecular study
dc.typeArticle


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