Genetic and Household Determinants of Predisposition to Human Hookworm Infection in a Brazilian Community

dc.creatorQuinnell, Rupert J.
dc.creatorPullan, Rachel L.
dc.creatorBreitling, Lutz Ph.
dc.creatorGeiger, Stefan Michael
dc.creatorCundill, Bonnie
dc.creatorOliveira, Rodrigo Correa de
dc.creatorBrooker, Simon
dc.creatorBethony, Jeffrey Michael
dc.date2018-08-01T16:04:42Z
dc.date2018-08-01T16:04:42Z
dc.date2010
dc.date.accessioned2023-09-26T22:56:43Z
dc.date.available2023-09-26T22:56:43Z
dc.identifierQUINNELL, Rupert J. et al. Genetic and Household Determinants of Predisposition to Human Hookworm Infection in a Brazilian Community. J Infect Dis., v. 202, n. 6, p. 954–961, Sept. 15, 2010.
dc.identifier0022-1899
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/27766
dc.identifier10.1086/655813
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8885059
dc.descriptionBackground: Predisposition to heavy or light human hookworm infection is consistentlyreported in treatment-reinfection studies. A significant role for host genetics in determining hookworm infection intensity has also been shown, but the relationship between host genetics and predisposition has not been investigated. Methods: A treatment-reinfection study was carried out on 1302 individuals in Brazil. Bivariate variance components analysis was used to estimate heritability for pretreatment and reinfection intensity, and to estimate the contribution of genetic and household correlations between phenotypes to the overall phenotypic correlation (i.e. predisposition). Results: Heritability for hookworm egg count was 17% pretreatment and 25% after reinfection. Predisposition to heavy or light hookworm infection was observed, with a phenotypic correlation of 0.34 between pretreatment and reinfection intensity. This correlation was reduced to 0.23 after including household and environmental covariates. Genetic and household correlations were 0.41 and 1 respectively, and explained 88% of the adjusted phenotypic correlation. Conclusions: Predisposition to human hookworm infection in this area results from a combination of host genetics and consistent differences in exposure, with the latter explained by household and environmental factors. Unmeasured individual-specific differences in exposure did not contribute to predisposition.
dc.description2025-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherUniversity of Chicago Press
dc.rightsrestricted access
dc.subjectHereditariedade
dc.subjectEpidemiologia
dc.subjectPredisposição
dc.subjectResistência
dc.subjectAnálise de componentes de variância
dc.subjectNecator americanus
dc.subjectHeritability
dc.subjectEpidemiology
dc.subjectPredisposition
dc.subjectResistance
dc.subjectVariance components analysis
dc.subjectNecator americanus
dc.titleGenetic and Household Determinants of Predisposition to Human Hookworm Infection in a Brazilian Community
dc.typeArticle


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