Food restriction-induced myocardial dysfunction demonstrated by the combination of in vivo and in vitro studies

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorOkoshi, Katashi
dc.creatorMatsubara, Luiz Shiguero
dc.creatorOkoshi, Marina Politi
dc.creatorCicogna, Antonio Carlos
dc.creatorFioretto, José Roberto
dc.creatorPadovani, Carlos Roberto
dc.creatorAragon, Flávio F
dc.creatorMatsubara, Beatriz Bojikian
dc.date2014-05-27T11:20:31Z
dc.date2016-10-25T18:18:02Z
dc.date2014-05-27T11:20:31Z
dc.date2016-10-25T18:18:02Z
dc.date2002-11-01
dc.date.accessioned2017-04-06T01:03:25Z
dc.date.available2017-04-06T01:03:25Z
dc.identifierNutrition Research, v. 22, n. 11, p. 1353-1364, 2002.
dc.identifier0271-5317
dc.identifierhttp://hdl.handle.net/11449/67003
dc.identifierhttp://acervodigital.unesp.br/handle/11449/67003
dc.identifier10.1016/S0271-5317(02)00454-2
dc.identifier2-s2.0-0036846992
dc.identifierhttp://dx.doi.org/10.1016/S0271-5317(02)00454-2
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/888501
dc.descriptionThe aim of this study was to test the hypothesis that protein-calorie undernutrition decreases myocardial contractility jeopardizing ventricular function, and that ventricular dysfunction can be detected noninvasively. Five-month-old male Wistar-Kyoto rats were fed with regular rat chow ad libitum for 90 days (Control group, n = 14). A second group of rats received 50% of the amount of diet consumed by de control group (Food restricted group, n = 14). Global LV systolic function was evaluated in vivo, noninvasively, by transthoracic echocardiogram. After echocardiographic study, myocardial contractility was assessed in vitro in the isovolumetrically beating isolated heart in eight animals from each group (Langendorff preparation). The in vivo LV fractional shortening showed that food restriction depressed LV systolic function (p < 0.05). Myocardial contractility was impaired as assessed by the maximal rate of rise of LV pressure (+dP/dt), and developed pressure at diastolic pressure of 25 mmHg (p < 0.05). Furthermore, food restriction induced eccentric ventricular remodeling, and reduced myocardial elasticity and LV compliance (p < 0.05). In conclusion, food restriction causes systolic dysfunction probably due to myocardial contractility impairment and reduction of myocardial elasticity. © 2002 Elsevier B.V. All rights reserved.
dc.languageeng
dc.relationNutrition Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCardiac function
dc.subjectEchocardiogram
dc.subjectLangendorff preparation
dc.subjectMalnutrition
dc.subjectUndernutrition
dc.subjectVentricular remodeling
dc.subjectanimal experiment
dc.subjectanimal food
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectcaloric restriction
dc.subjectcontrolled study
dc.subjectelasticity
dc.subjectheart left ventricle compliance
dc.subjectheart left ventricle contraction
dc.subjectheart muscle contractility
dc.subjectheart ventricle function
dc.subjectheart ventricle remodeling
dc.subjectimage analysis
dc.subjectisolated heart
dc.subjectmale
dc.subjectmyocardial disease
dc.subjectnon invasive measurement
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectprotein calorie malnutrition
dc.subjectprotein restriction
dc.subjectrat
dc.subjectrat strain
dc.subjecttransthoracic echocardiography
dc.subjectAnimalia
dc.titleFood restriction-induced myocardial dysfunction demonstrated by the combination of in vivo and in vitro studies
dc.typeOtro


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