Pluripotent‑derived mesenchymal stem/stromal cells: an overview of the derivation protocol efficacies and the differences among the derived cells

dc.creatorMatos, Bruno Moisés de
dc.creatorRobert, Anny Waloski
dc.creatorStimamiglio, Marco Augusto
dc.creatorCorrea, Alejandro
dc.date2021-11-09T13:43:55Z
dc.date2021-11-09T13:43:55Z
dc.date2021
dc.date.accessioned2023-09-26T22:55:49Z
dc.date.available2023-09-26T22:55:49Z
dc.identifierMATOS, Bruno Moisés de et al. Pluripotent‑derived mesenchymal stem/stromal cells: an overview of the derivation protocol efficacies and the differences among the derived cells. Stem Cell Reviews and Reports, p. 1–32, 2021.
dc.identifier1558-6804
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/49742
dc.identifier10.1007/s12015-021-10258-z
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884880
dc.descriptionMesenchymal stem/stromal cells (MSCs) are remarkable tools for regenerative medicine. Therapeutic approaches using these cells can promote increased activity and viability in several cell types through diverse mechanisms such as paracrine and immunomodulatory activities, contributing substantially to tissue regeneration and functional recovery. However, biological samples of human MSCs, usually obtained from adult tissues, often exhibit variable behavior during in vitro culture, especially with respect to cell population heterogeneity, replicative senescence, and consequent loss of functionality. Accordingly, it is necessary to establish standard protocols to generate high-quality, stable cell cultures, for example, by using pluripotent stem cells (PSCs) in derivation protocols of MSC-like cells since PSCs maintain their characteristics consistently during culture. However, the available protocols seem to generate distinct populations of PSC-derivedMSCs (PSC-MSCs) with peculiar attributes, which do not always resemble bona fde primary MSCs. The present review addresses the developmental basis behind some of these derivation protocols, exposing the diferences among them and discussing the functional properties of PSC-MSCs, shedding light on elements that may help determine standard characterizations and criteria to evaluate and defne these cells.
dc.formatapplication/pdf
dc.languagepor
dc.publisherSpringer
dc.rightsrestricted access
dc.subjectMesenchymal Stem Cells
dc.subjectPluripotent Stem Cells
dc.subjectProtocols
dc.subjectTherapeutics
dc.subjectCélulas Madre Mesenquimatosas
dc.subjectCélulas Madre Pluripotentes
dc.subjectTerapéutica
dc.subjectCellules souches mésenchymateuses
dc.subjectCellules souches pluripotentes
dc.subjectProtocoles
dc.subjectThérapeutique
dc.subjectCélulas-Tronco Mesenquimais
dc.subjectCélulas-Tronco Pluripotentes
dc.subjectProtocolos
dc.subjectTerapêutica
dc.titlePluripotent‑derived mesenchymal stem/stromal cells: an overview of the derivation protocol efficacies and the differences among the derived cells
dc.typeArticle


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