A Promising Future for Stem-Cell-Based Therapies in Muscular Dystrophies-In Vitro and In Vivo Treatments to Boost Cellular Engraftment

dc.creatorBeghini, Daniela Gois
dc.creatorHorita, Samuel Iwao
dc.creatorCardoso, Liana Monteiro da Fonseca
dc.creatorAlves, Luiz Anastacio
dc.creatorNagaraju, Kanneboyina
dc.creatorHenriques-Pons, Andrea
dc.date2020-03-30T20:13:43Z
dc.date2020-03-30T20:13:43Z
dc.date2019
dc.date.accessioned2023-09-26T22:55:32Z
dc.date.available2023-09-26T22:55:32Z
dc.identifierBEGHINI, Daniela Gois et al. A Promising Future for Stem-Cell-Based Therapies in Muscular Dystrophies—In Vitro and In Vivo Treatments to Boost Cellular Engraftment. International Journal of Molecular Sciences, v. 20, n. 5433, p. 1-26, Oct. 2019.
dc.identifier1661-6596
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/40566
dc.identifier10.3390/ijms20215433
dc.identifier1422-0067
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884826
dc.descriptionMuscular dystrophies (MD) are a group of genetic diseases that lead to skeletal muscle wasting and may affect many organs (multisystem). Unfortunately, no curative therapies are available at present for MD patients, and current treatments mainly address the symptoms. Thus, stem-cell-based therapies may present hope for improvement of life quality and expectancy. Different stem cell types lead to skeletal muscle regeneration and they have potential to be used for cellular therapies, although with several limitations. In this review, we propose a combination of genetic, biochemical, and cell culture treatments to correct pathogenic genetic alterations and to increase proliferation, dispersion, fusion, and differentiation into new or hybrid myotubes. These boosted stem cells can also be injected into pretreate recipient muscles to improve engraftment. We believe that this combination of treatments targeting the limitations of stem-cell-based therapies may result in safer and more efficient therapies for MD patients. Matricryptins have also discussed.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectDistrofia muscular
dc.subjectTerapia de células-tronco
dc.subjectRegeneração muscular
dc.subjectMatricryptins e matrikines
dc.subjectInflamação
dc.subjectMuscular dystrophy
dc.subjectStem cells therapy
dc.subjectMuscle regeneration
dc.subjectMatricryptins and matrikines
dc.subjectInflammation
dc.titleA Promising Future for Stem-Cell-Based Therapies in Muscular Dystrophies-In Vitro and In Vivo Treatments to Boost Cellular Engraftment
dc.typeArticle


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