Evaluation of SPf66 malaria vaccine efficacy in Brazil

dc.creatorUrdaneta, Margarita
dc.creatorPrata, Aluizio
dc.creatorStruchiner, Claudio J.
dc.creatorTosta, C. Eduardo
dc.creatorTauil, Pedro
dc.creatorBoulos, Marcos
dc.date2018-10-09T14:55:45Z
dc.date2018-10-09T14:55:45Z
dc.date1998
dc.date.accessioned2023-09-26T22:55:16Z
dc.date.available2023-09-26T22:55:16Z
dc.identifierURDANETA, Margarita et al. Evaluation of SPf66 malaria vaccine efficacy in Brazil. American Journal of Tropical Medicine and Hygiene, v. 58, n. 3, p. 378-385, 1998.
dc.identifier0002-9637
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/29464
dc.identifier10.4269/ajtmh.1998.58.378
dc.identifier0002-9637
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884773
dc.descriptionThis paper reports the efficacy results of the randomized, placebo-controlled, field trial of SPf66 malaria vaccine in Costa Marques, Rondonia, Brazil. This region is characterized by the seasonal distribution of Plasmodium falciparum and P. vivax infections, and the recent occupation by migrants from nonendemic areas. A total of 800 individuals of both sexes, ranging in age from seven to 60 years, were included in the study. Of the initial cohort, 572 participants completed the vaccination schedule. Clinical and parasitologic evaluations were obtained by active and passive searches on a periodic basis. The overall protective efficacy against P. falciparum infections was -1.6% (-32.9% to 22.4%), and 14.1% (-17.0% to 36.9%) for the first episode. The overall protective efficacy for P. vivax infections was -19.7% (-44.8% to 1.03%), and -10.8% (-41.1% to 12.8%) for the first episode. No statistical evidence of an overall significant protective effect of SPf66 malaria vaccine against P. falciparum and P. vivax malaria was obtained in this trial.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Society of Tropical Medicine and Hygiene
dc.rightsopen access
dc.subjectAméricas
dc.subjectBrasil
dc.subjectAssistência à Saúde
dc.subjectPaíses em Desenvolvimento
dc.subjectDoença
dc.subjectAssistência Ambulatorial
dc.subjectImunização
dc.subjectAmérica Latina
dc.subjectMalária
dc.subjectOrganização e Administração
dc.subjectDoenças Parasitárias
dc.subjectAtenção Primária à Saúde
dc.subjectAvaliação de Programas e Projetos de Saúde
dc.subjectProjetos de Pesquisa
dc.subjectRelatório de Pesquisa
dc.subjectAmérica do Sul
dc.subjectVacinação
dc.subjectAmericas
dc.subjectBrazil
dc.subjectClinical Research
dc.subjectDelivery of Health Care
dc.subjectDeveloping Countries
dc.subjectDiseases
dc.subjectHealth Services
dc.subjectImmunization
dc.subjectLatin America
dc.subjectMalaria-prevention and control
dc.subjectOrganization and Administration
dc.subjectParasitic Diseases
dc.subjectPrimary Health Care
dc.subjectProgram Evaluation
dc.subjectResearch Methodology
dc.subjectResearch Report
dc.subjectSouth America
dc.subjectVaccination and Vaccines
dc.subjectAmericas
dc.subjectBrazil
dc.subjectDelivery of Health Care
dc.subjectDeveloping Countries
dc.subjectDisease
dc.subjectImmunization
dc.subjectLatin America
dc.subjectMalaria
dc.subjectOrganization and Administration
dc.subjectParasitic Diseases
dc.subjectPrimary Health Care
dc.subjectProgram Evaluation
dc.subjectResearch Report
dc.subjectSouth America
dc.subjectVaccination
dc.titleEvaluation of SPf66 malaria vaccine efficacy in Brazil
dc.typeArticle


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