Evidencing the Role of Erythrocytic Apoptosis in Malarial Anemia

dc.creatorTotino, Paulo R. R.
dc.creatorDaniel-Ribeiro, Cláudio Tadeu
dc.creatorCruz, Maria de Fátima Ferreira da
dc.date2017-03-01T17:16:40Z
dc.date2017-03-01T17:16:40Z
dc.date2016
dc.date.accessioned2023-09-26T22:55:15Z
dc.date.available2023-09-26T22:55:15Z
dc.identifierTOTINO, Paulo R. R.; RIBEIRO, Claudio T. Daniel; CRUZ, Maria de Fátima Ferreira da. Evidencing the role of Erythrocytic Apoptosis in Malarial Anemia. Frontiers in Cellular and Infection Microbiology, v.6, Article 176, 11p, Dec. 2016.
dc.identifier2235-2988
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/17912
dc.identifier10.3389/fcimb.2016.00176
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884768
dc.descriptionIn the last decade it has become clear that, similarly to nucleated cells, enucleated red blood cells (RBCs) are susceptible to programmed apoptotic cell death. Erythrocytic apoptosis seems to play a role in physiological clearance of aged RBCs, but it may also be implicated in anemia of different etiological sources including drug therapy and infectious diseases. In malaria, severe anemia is a common complication leading to death of children and pregnant women living in malaria-endemic regions of Africa. The pathogenesis of malarial anemia is multifactorial and involves both ineffective production of RBCs by the bone marrow and premature elimination of non-parasitized RBCs, phenomena potentially associated with apoptosis. In the present overview, we discuss evidences associating erythrocytic apoptosis with the pathogenesis of severe malarial anemia, as well as with regulation of parasite clearance in malaria. Efforts to understand the role of erythrocytic apoptosis in malarial anemia can help to identify potential targets for therapeutic intervention based on apoptotic pathways and consequently, mitigate the harmful impact of malaria in global public health.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectMalária
dc.subjectAnemia
dc.subjectApoptose
dc.subjectFagocitose
dc.subjectEritrócitos
dc.subjectMalaria
dc.subjectAnemia
dc.subjectApoptosis
dc.subjectred blood cells
dc.subjectphagocytosis
dc.titleEvidencing the Role of Erythrocytic Apoptosis in Malarial Anemia
dc.typeArticle


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