Lifewide profile of cytokine production by innate and adaptive immune cells from Brazilian individuals

dc.creatorNunes, Gabriela Silveira
dc.creatorSpeziali, Elaine
dc.creatorCarvalho, Andréa Teixeira de
dc.creatorAvelar, Danielle Vitele Marquete
dc.creatorAvelar, Renato Sathler
dc.creatorSoares, Taciana Figueiredo
dc.creatorSilva, Maria Luiza
dc.creatorPascoal, Vanessa Peruhype Magalhães
dc.creatorChaves, Daniel Gonçalves
dc.creatorMelo, Gustavo Eustáquio Brito
dc.creatorCardoso, Glenda Meira
dc.creatorSoares, Eric Bassetti
dc.creatorSantos, Silvana Maria Elói
dc.creatorTeixeira, Rosângela
dc.creatorQueiroz, Dulciene Magalhães
dc.creatorOliveira, Rodrigo Corrêa de
dc.creatorFaria, Ana Maria Caetano
dc.creatorMartins Filho, Olindo Assis
dc.date2018-06-07T17:58:30Z
dc.date2018-06-07T17:58:30Z
dc.date2017
dc.date.accessioned2023-09-26T22:54:59Z
dc.date.available2023-09-26T22:54:59Z
dc.identifierNUNES, Gabriela Silveira et al. Lifewide profile of cytokine production by innate and adaptive immune cells from Brazilian individuals. Immun Ageing., v. 14, 2, 2017
dc.identifier1742-4933
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/26782
dc.identifier10.1186/s12979-017-0084-5
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884718
dc.descriptionBackground: Immunosenescence is associated with several changes in adaptive and innate immune cells. Altered cytokine production is among the most prominent of these changes. The impact of age-related alterations on cytokine global profiles produced by distinct populations of leukocytes from healthy Brazilian individuals was studied. We analysed frequencies of cytokine-producing lymphocytes and innate immune cells from individuals at several ages spanning a lifetime period (0–85 years). Results: Healthy adult individuals presented a balanced profile suggestive of a mature immune system with equal contributions of both innate and adaptive immunity and of both categories of cytokines (inflammatory and regulatory). In healthy newborns and elderly, innate immune cells, especially neutrophils and NK-cells, contributed the most to a balanced profile of cytokines. Conclusions: Our results support the hypothesis that ageing is not associated with a progressive pro-inflammatory cytokine production by all leukocytes but rather with distinct fluctuations in the frequency of cytokine-producing cells throughout life.
dc.description2020-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherBioMed Central
dc.rightsopen access
dc.subjectidade
dc.subjectcitocinas
dc.subjectadaptação de celulas imune
dc.subjectimunidadade nata
dc.subjectAging
dc.subjectCytokine
dc.subjectAdaptive immune cells
dc.subjectInnate immune cells
dc.titleLifewide profile of cytokine production by innate and adaptive immune cells from Brazilian individuals
dc.typeArticle


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