Inflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging

dc.creatorAmorim, Juleimar Soares Coelho de
dc.creatorTorres, Karen Cecília Lima
dc.creatorCarvalho, Andréa Teixeira de
dc.creatorMartins Filho, Olindo Assis
dc.creatorCosta, Maria Fernanda Furtado Lima
dc.creatorPeixoto, Sérgio William Viana
dc.date2019-10-18T19:04:45Z
dc.date2019-10-18T19:04:45Z
dc.date2019
dc.date.accessioned2023-09-26T22:54:47Z
dc.date.available2023-09-26T22:54:47Z
dc.identifierAMORIM, Juleimar Soares Coelho de et al. Inflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging. Revista de Saúde Pública, v. 53, p. 1-11, 2019.
dc.identifier0034-8910
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/36587
dc.identifier10.11606/s1518-8787.2019053000855
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884677
dc.descriptionOBJECTIVE: Analyze whether inflammatory markers are associated with falls among older adults living in Bambuí. METHODS: Study that analyzed baseline data from a Bambuí Cohort Study of Aging, involving 1,250 participants. Data about falls were collected from previous 12 months, classified as single or multiple occurrence and severity (participant seeking health services). Information about sociodemographic characteristics, health behaviors and health condition was also collected and used as confounding factors. The exposures of interest included interleukins (IL-1β, IL-6, IL-8, IL-10, IL-12), tumor necrosis factor (TNF), ultra-sensitive C-reactive protein (us-CRP) and chemokines (CXCL9, CCL5, CCL10, MCP1). Data were processed through logistic regression, obtaining odds ratio and 95% confidence interval (95%CI). RESULTS: The prevalence of falls was 27.1%; 40.1% of the older adults reported multiple falls and 33.3% sought health services. After adjustments, the following elevated levels were associated with falls: us-CRP (OR = 1.46, 95%CI 1.04–2.03), CCL5 (OR = 1.38, 95%CI 1.01–1.90) and CXCL9 (OR = 1.43, 95%CI 1.02–2.02). An association was observed between the number of elevated markers and the occurrence of falls: two (OR = 1.47, 95%CI 1.02–2.12) and three (OR = 2.08, 95%CI 1.12–3.87) elevated biomarkers indicated fall probability of 32.0% and 39.4%, respectively. CONCLUSIONS: Elevated levels of us-CRP, CCL5 and CXCL9, which were associated with falls, may contribute to a proper understanding of the mechanism associated with the occurrence of falls among older people.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFaculdade de Saúde Pública da Universidade de São Paulo
dc.rightsopen access
dc.subjectAged
dc.subjectAging
dc.subjectAccidental Falls
dc.subjectRisk Factors
dc.subjectBiomarkers
dc.subjectInflammation Mediators
dc.titleInflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging
dc.typeArticle


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