| dc.creator | Gentile, Rosana | |
| dc.creator | Oliveira, Guilherme | |
| dc.date | 2019-03-07T15:52:11Z | |
| dc.date | 2019-03-07T15:52:11Z | |
| dc.date | 2008 | |
| dc.date.accessioned | 2023-09-26T22:54:21Z | |
| dc.date.available | 2023-09-26T22:54:21Z | |
| dc.identifier | GENTILE, Rosana; OLIVEIRA, Guilherme. Brazilian studies on the genetics of Schistosoma mansoni. Acta Tropica, v.108, n.2-3.p.175-178, 2008. | |
| dc.identifier | 0001-706X | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/31978 | |
| dc.identifier | 10.1016/j.actatropica.2008.09.003 | |
| dc.identifier | 1873-6254 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8884594 | |
| dc.description | The parasite Schistosoma is known to exhibit variations among species, strains and genera, such as,
the levels of infectivity, pathogenicity and immunogenicity. These factors may differ among parasite
populations according to the local epidemiological conditions. Diversity observed in S. mansoni from
different geographical regions or within individuals of the same region can be determined by
differences in the genotype of each parasite strain. However, until recently, finding adequate genetic
markers to investigate infectivity or other epidemiological characteristics of a transmission area
proved difficult. Several studies have been conducted to evaluate the genetic variability of S.
mansoni, using different techniques. Intraspecific variability was observed in morphological
characters, isoenzyme studies, mtDNA, ribosomal gene probes, RAPD and microsatellites. The
sequencing of the S. mansoni genome was the most important achievement concerning genetic
approaches to the study of this parasite and may improve the development of drugs, vaccines and
diagnostics of schistosomiasis. The knowledge of the genetic structure of schistosome populations
in relation to epidemiological data and host variability is essential for the understanding of the
epidemiology of the disease and the design of control strategies. | |
| dc.description | 2022-01-01 | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Elsevier 12 Months | |
| dc.rights | restricted access | |
| dc.subject | Schistosoma mansoni | |
| dc.subject | Brasil | |
| dc.subject | Genética | |
| dc.subject | Estudos | |
| dc.subject | Schistosoma mansoni | |
| dc.subject | Brazil | |
| dc.subject | Studies | |
| dc.subject | Genetics | |
| dc.title | Brazilian studies on the genetics of Schistosoma mansoni | |
| dc.type | Article | |
