Patterns in Leptospira Shedding in Norway Rats (Rattus norvegicus) from Brazilian Slum Communities at High Risk of Disease Transmission.

dc.creatorCosta, Federico
dc.creatorWunder Junior, Elsio Augusto
dc.creatorOliveira, Daiana de
dc.creatorBisht, Vimla
dc.creatorRodrigues, Gorete
dc.creatorReis, Mitermayer Galvão dos
dc.creatorKo, Albert Icksang
dc.creatorBegon, Mike
dc.creatorChilds, James E
dc.date2015-07-08T17:56:52Z
dc.date2015-07-08T17:56:52Z
dc.date2015
dc.date.accessioned2023-09-26T22:53:51Z
dc.date.available2023-09-26T22:53:51Z
dc.identifierCOSTA, F. et al. Patterns in Leptospira Shedding in Norway Rats (Rattus norvegicus) from Brazilian Slum Communities at High Risk of Disease Transmission. PLoS Neglected Tropical Diseases, v. 9, n. 6, p.e0003819, 2015
dc.identifier1935-2735
dc.identifier10.1371/journal.pntd.0003819
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/11174
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884503
dc.descriptionBACKGROUND: We address some critical but unknown parameters of individuals and populations of Norway rats (Rattus norvegicus) that influence leptospiral infection, maintenance and spirochetal loads shed in urine, which contaminates the environment ultimately leading to human infection. METHODOLOGY/PRINCIPAL FINDINGS: Our study, conducted in Salvador, Brazil, established the average load of leptospires in positive kidneys to be 5.9 x 106 per mL (range 3.1-8.2 x106) genome equivalents (GEq), similar to the 6.1 x 106 per ml (range 2.2-9.4 x106) average obtained from paired urines, with a significant positive correlation (R2=0.78) between the two. Based on bivariate and multivariate modeling, we found with both kidney and urine samples that leptospiral loads increased with the age of rats (based on the index of body length to mass), MAT titer and the presence of wounding/scars, and varied with site of capture. Some associations were modified by sex but trends were apparent. Combining with data on the demographic properties and prevalence of leptospiral carriage in rat populations in Salvador, we estimated that daily leptospiral loads shed in the urine of a population of 82 individuals exceeded 9.1 x 1010 leptospires. CONCLUSIONS/SIGNIFICANCE: These factors directly influence the risk of leptospiral acquisition among humans and provide essential epidemiological information linking properties of rat populations with risk of human infection.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectLeptospirose
dc.subjectLeptospira
dc.subjectInfecção
dc.subjectHumanos
dc.subjectTransmissão
dc.subjectRattus norvegicus
dc.subjectRatos
dc.subjectAnimal
dc.titlePatterns in Leptospira Shedding in Norway Rats (Rattus norvegicus) from Brazilian Slum Communities at High Risk of Disease Transmission.
dc.typeArticle


Este ítem pertenece a la siguiente institución