Competence of non-human primates to transmit Leishmania infantum to the invertebrate vector Lutzomyia longipalpis

dc.creatorOliveira, Ayisa Rodrigues de
dc.creatorPinheiro, Guilherme Rafael Gomide
dc.creatorTinoco, Herlandes P.
dc.creatorLoyola, Maria Elvira
dc.creatorCoelho, Carlyle Mendes
dc.creatorDias, Edelberto Santos
dc.creatorMonteiro, Érika Michalsky
dc.creatorSilva, Fabiana de Oliveira Lara e
dc.creatorPessanha, Angela Tinoco
dc.creatorSouza, Andreza Geisiane Maia
dc.creatorPereira, Nathália Cristina Lima
dc.creatorFujiwara, Ricardo Toshio
dc.creatorPaixão, Tatiane Alves da
dc.creatorSantos, Renato Lima
dc.date2019-08-27T16:12:01Z
dc.date2019-08-27T16:12:01Z
dc.date2019
dc.date.accessioned2023-09-26T22:53:49Z
dc.date.available2023-09-26T22:53:49Z
dc.identifierOLIVEIRA, Ayisa Rodrigues de et al. Competence of non-human primates to transmit Leishmania infantum to the invertebrate vector Lutzomyia longipalpis. PLoS Neglected Tropical Diseases, v. 13, n. 4, p. 1-14, 2019.
dc.identifier1935-2735
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/35117
dc.identifier10.1371/journal.pntd.0007313
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884495
dc.descriptionLeishmaniasis is a zoonotic disease of worldwide relevance. Visceral leishmaniasis is endemic in Brazil, where it is caused by Leishmania infantum with Lutzomyia longipalpis being the most important invertebrate vector. Non-human primates are susceptible to L. infantum infection. However, little is known about the role of these species as reservoirs. The aim of this study was to evaluate the transmissibility potential of visceral leishmaniasis by non-human primates through xenodiagnosis using the phlebotomine Lu. longipalpis as well as to identify phlebotomine species prevalent in the area where the primates were kept in captivity, and assess infection by Leishmania in captured phlebotomine specimens. Fifty two non-human primates kept in captivity in an endemic area for leishmaniasis were subjected to xenodiagnosis. All primates were serologically tested for detection of anti-Leishmania antibodies. Additionally, an anti-Lu. longipalpis saliva ELISA was performed. Sand flies fed on all animals were tested by qPCR to identify and quantify L. infantum promastigotes. Eight of the 52 non-human primates were positive by xenodiagnosis, including three Pan troglodytes, three Leontopithecus rosalia, one Sapajus apella, and one Miopithecus talapoin, with estimated numbers of promastigotes ranging from 5.67 to 1,181.93 per μg of DNA. Positive animals had higher levels of IgG anti-Lu. longipalpis saliva when compared to negative animals, prior to xenodiagnosis. Captive non-human primates are capable of infecting Lu. longipalpis with L. infantum. Our findings also demonstrate the relevance of non-human primates as sentinels to zoonotic diseases. Several phlebotomine species, including Lu. longipalpis, have been identified in the area where the primates were maintained, but only one pool of Lutzomyia lenti was infected with L. infantum. This study has implications for public health strategies and conservation medicine.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectLeishmaniasis
dc.subjectVisceral leishmaniasis
dc.titleCompetence of non-human primates to transmit Leishmania infantum to the invertebrate vector Lutzomyia longipalpis
dc.typeArticle


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