HPLC-DAD-ESI-MS profile, antibacterial activity, and modulation of the activity of antibiotics by Carica papaya L. against Escherichia coli serotypes

dc.creatorGondim, Cícera Natalia Figueiredo Leite
dc.creatorBezerra, Denise Aline Casimiro
dc.creatorSampaio, Nadghia Figueiredo Leite
dc.creatorAlencar, Maria Anésia Sousa de
dc.creatorCosta, Roger Henrique Sousa da
dc.creatorAbreu, Lucas Silva
dc.creatorSilva, Joanda Paolla Raimundo e
dc.creatorPereira Junior, Francisco Nascimento
dc.creatorTavares, Josean Fechine
dc.creatorSilva, Marcelo Sobral da
dc.creatorRibeiro Filho, Jaime
dc.creatorCoutinho, Henrique Douglas Melo
dc.date2022-10-13T14:10:13Z
dc.date2022-10-13T14:10:13Z
dc.date2022
dc.date.accessioned2023-09-26T22:53:28Z
dc.date.available2023-09-26T22:53:28Z
dc.identifierGONDIM, Cícera Natalia Figueiredo Leite et al. HPLC-DAD-ESI-MS profile, antibacterial activity, and modulation of the activity of antibiotics by Carica papaya L. against Escherichia coli serotypes. Phytomedicine Plus, v. 2, n. 4, p. 1-6, 2022.
dc.identifier2667-0313
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/55123
dc.identifier10.1016/j.phyplu.2022.100306
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884429
dc.descriptionFundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico – FUNCAP.
dc.descriptionBackground: Diarrhea is currently the second leading cause of death among children under five years old in the world and therefore, remains a global public health problem. Considering that most cases of diarrhea are due to gastrointestinal infections, and medicinal plants have been traditionally used to treat such conditions, this work aimed to evaluate the chemical composition, antibacterial activity, and antibiotic-enhancing properties of C. papaya against Escherichia coli, EPEC (Enteropathogenic E. coli), and ETEC (Enterotoxigenic E. coli) serotypes. Methods: The chemical profile of the aqueous extract obtained from C. papaya leaves was determined by HPLC-DAD-ESI-MS. The antibacterial and antibiotic-enhancing activities were evaluated through the determination of the MIC, following the microdilution method. Results: A total of 17 compounds were identified by HPLC-DAD-ESI-MS. However, the extract of C. papaya did not present an intrinsic antibacterial effect, in addition to showing no modulatory effect when associated with antibiotics. Conclusions: Despite the presence of bioactive compounds, the aqueous extract C. papaya does not present antibacterial or antibiotic-enhancing effects against the ETEC and EPEC strains of E. coli. Nevertheless, further research is required to determine if its isolated components are potential drug candidates for the therapy of infections caused by these strains.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectCarica
dc.subjectAntibiotic Resistance
dc.subjectCarica mamão
dc.subjectHPLC-DAD-ESI-MS
dc.subjectAtividade antibacteriana
dc.subjectResistência a antibióticos
dc.subjectE․ coli
dc.subjectCarica papaya
dc.subjectHPLC-DAD-ESI-MS
dc.subjectAntibacterial activity
dc.subjectAntibiotic resistance
dc.subjectE․ coli
dc.titleHPLC-DAD-ESI-MS profile, antibacterial activity, and modulation of the activity of antibiotics by Carica papaya L. against Escherichia coli serotypes
dc.typeArticle


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