Evaluation of an IFN-gamma assay in the diagnosis of latent tuberculosis in patients with psoriasis in a highly endemic setting

dc.creatorLima, Emerson de Andrade
dc.creatorLima, Mariana de Andrade
dc.creatorLorena, Virgínia M. Barros de
dc.creatorGomes, Yara de Miranda
dc.creatorLupi, Omar
dc.creatorBenard, Gil
dc.date2018-09-11T11:45:04Z
dc.date2018-09-11T11:45:04Z
dc.date2011
dc.date.accessioned2023-09-26T22:53:26Z
dc.date.available2023-09-26T22:53:26Z
dc.identifierDE ANDRADE LIMA, E. et al. Evaluation of an IFN-gamma assay in the diagnosis of latent tuberculosis in patients with psoriasis in a highly endemic setting. Acta Dermato-Venereologica, v. 91, n. 6, p. 694–697, out. 2011.
dc.identifier1651-2057
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/28620
dc.identifier10.2340/00015555-1151
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884419
dc.descriptionFundação de Amparo a Pesquisa de São Paulo número de concessão 2008 / 57608-2
dc.descriptionScreening for latent tuberculosis infection is mandatory before starting anti-tumour necrosis factor treatments, but its diagnosis still poses a challenge. While studies performed in developed countries have demonstrated superior performance of T-cell based interferon-γ release assay (IGRA) compared with the tuberculin skin test, there is a debate about whether this holds true in tuberculosis endemic areas. The performance of an IGRA kit T-SPOT.TB was evaluated in 33 moderate-to-severe untreated psoriasis patients and, as controls, 30 patients with common dermatological diseases at a tuberculosis highly endemic setting. The frequency of positive tuberculin skin test responses and induration size in controls were higher than in psoriasis patients (53% vs. 18% and 9.3 ± 1.4 vs. 2.6 ± 0.7 mm, respectively, p < 0.001). In contrast, the frequency of positive response and mean number of spots elicited with the T-SPOT.TB test were not significantly different between patients and controls (47% vs. 43% and 14.7 ± 3.2 vs. 20.5 ± 3.1 spots/well, respectively). The two tests presented good agreement in the control, but not the psoriasis group (κ values of 0.625 and 0.375, respectively). Thus, in a highly tuberculosis-endemic setting the T-SPOT.TB test was superior to the tuberculin skin test in diagnosing latent tuberculosis infection in psoriasis, probably because the immune dysregulation of psoriasis shows a lower interference in the in vitro test.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectTuberculose Latente
dc.subjectPsoríase
dc.subjectFatores de Necrose Tumoral
dc.subjectTeste em pele tuberculina
dc.subjectEnsaio de libertação de interferão-gama;
dc.subjectELISPOT
dc.subjectLatent tuberculosis infection
dc.subjectPsoriasis
dc.subjectTNF
dc.subjecttuberculin skin test
dc.subjectInterferon-γ release assay
dc.subjectELISPOT
dc.subjectAntígenos Bacterianos / imunologia
dc.subjectProteínas Bacterianas / imunologia
dc.subjectBrasil
dc.subjectEstudos Transversais
dc.subjectTestes de Liberação de Interferon-gama
dc.subjectTuberculose latente / complicações
dc.subjectTuberculose Latente / diagnóstico
dc.subjectTuberculose Latente / imunologia
dc.subjectMycobacterium tuberculosis / imunologia
dc.subjectPsoríase / complicações
dc.titleEvaluation of an IFN-gamma assay in the diagnosis of latent tuberculosis in patients with psoriasis in a highly endemic setting
dc.typeArticle


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