Repeatability and Diagnostic Value of Nasal Potential Difference in a Genetically Admixed Population

dc.creatorSad, Izabela Rocha
dc.creatorHiga, Laurinda Yoko Shinzato
dc.creatorLeal, Teresinha
dc.creatorMartins, Raisa da Silva
dc.creatorAlmeida, Ana Claudia de
dc.creatorRamos, Eloane Goncalves
dc.creatorCabello, Giselda Maria Kalil de
dc.creatorPeixoto, Maria Virginia Marques
dc.date2017-03-21T11:48:36Z
dc.date2017-03-21T11:48:36Z
dc.date2016
dc.date.accessioned2023-09-26T22:53:25Z
dc.date.available2023-09-26T22:53:25Z
dc.identifierSAD, Izabela Rocha; et al. Repeatability and Diagnostic Value of Nasal Potential Difference in a Genetically Admixed Population. J. Clin. Med. Res., v.8, n.1, p.15-24, 2016.
dc.identifier1918-3003
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/18090
dc.identifier10.14740/jocmr2312w
dc.identifier1918-3011
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884417
dc.descriptionThe genetic diversity of the Brazilian population results from three ethnic groups admixture: Europeans, Africans and Amerindians, thus increasing the difficulty of performing cystic fibrosis (CF) diagnosis. The nasal potential difference (NPD) evaluates the cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC) activity. Despite being a useful CF diagnostic test and a biomarker of CFTR-modulator drugs, it is also highly operator dependent. Therefore, it may be difficult to get accurate results and to interpret them. Wilschanski and Sermet scores were proposed to address these issues. This study aimed to evaluate repeatability and diagnostic value of NPD parameters and Wilschanski and Sermet scores in a CF center in Rio de Janeiro.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElmer Press
dc.rightsopen access
dc.subjectFibrose cística
dc.subjectDiferença de potencial nasal
dc.subjectTeste de diagnostico
dc.subjectRepetibilidade
dc.subjectÍndice de Wilschanski
dc.subjectCystic fibrosis
dc.subjectNasal potential difference
dc.subjectDiagnostic test
dc.subjectRepeatability
dc.subjectWilschanski index
dc.subjectSermet score
dc.titleRepeatability and Diagnostic Value of Nasal Potential Difference in a Genetically Admixed Population
dc.typeArticle


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